Integrated Continuous Biomanufacturing: Industrialization on the Horizon
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DOI: 10.1002/biot.201800722
Abstract: Continuous bioprocessing has the inherent advantage of higher productivity, which can facilitate implementation of small process trains resulting in cost-effective, lean, and agile manufacturing facilities. Impressive technological advances to enable continuous bioprocessing have been made… read more here.
Keywords: continuous bioprocessing; industrialization horizon; biomanufacturing industrialization; continuous biomanufacturing ... See more keywords
Adaptive Evolution in Producing Microtiter Cultivations Generates Genetically Stable Escherichia coli Production Hosts for Continuous Bioprocessing
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DOI: 10.1002/biot.202000376
Abstract: The production of recombinant proteins usually reduces cell fitness and the growth rate of producing cells. The growth disadvantage favors faster‐growing non‐producer mutants. Therefore, continuous bioprocessing is hardly feasible in Escherichia coli due to the… read more here.
Keywords: continuous bioprocessing; production; escherichia coli; long term ... See more keywords