Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.12.021
Abstract: Abstract The objective of this study was to devise robust and stable continuous manufacturing process settings, by exploring the design space after an investigation of the lubrication‐based parameters influencing the continuous direct compression tableting of… read more here.
Keywords: compression tableting; continuous direct; direct compression; design space ... See more keywords
Continuous direct compression as manufacturing platform for sustained release tablets.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.01.010
Abstract: This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two… read more here.
Keywords: methocel; continuous direct; direct compression; sustained release ... See more keywords
Integrated modeling of a continuous direct compression tablet manufacturing process: A production scale case study
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DOI: 10.1016/j.powtec.2019.05.078
Abstract: Abstract A flowsheet model for a continuous direct compression tableting process is developed and applied to process data generated at production scale. The model contains powder feeding, blending and tablet compaction unit operations. The dataset… read more here.
Keywords: tablet; continuous direct; process; model ... See more keywords
Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides
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DOI: 10.1039/c7re00164a
Abstract: The continuous production of benzyl amides by anodic oxidation in flow was developed. The stability and productivity of the equipment was examined over time and monitored by means of in-line UV analysis. The applicability of… read more here.
Keywords: oxidation; direct anodic; continuous direct; anodic flow ... See more keywords
Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15061587
Abstract: The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively low number… read more here.
Keywords: compression cdc; continuous direct; powder cohesion; powder ... See more keywords