Hybrid continuous reassessment method with overdose control for safer dose escalation.
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DOI: 10.1080/10543406.2023.2170401
Abstract: Phase 1 oncology studies focus on safety of novel treatments and identifying a dose associated with acceptable toxicity level. Various model-based designs have been proposed for guiding dose escalation and estimating maximum tolerated dose in… read more here.
Keywords: continuous reassessment; dose escalation; hybrid continuous; overdose control ... See more keywords