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Published in 2017 at "Steroids"
DOI: 10.1016/j.steroids.2017.07.010
Abstract: &NA; Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3‐oxo‐14&agr;‐hydroxy‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (2), 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3,11‐dioxo‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (3), 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3,12‐dioxo‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (4), and 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3‐oxo‐11&bgr;,14&agr;‐dihydroxy‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (5), along with a known metabolite, 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3‐oxo‐11&agr;‐dihydroxy‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (6).…
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Keywords:
contraceptive drug;
bgr;
agr;
bgr bgr ... See more keywords