Loopholes in the DNA contract kill neurons
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4626
Abstract: Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism… read more here.
Keywords: dna contract; kill neurons; loopholes dna; contract kill ... See more keywords
Contract to kill: GNAS mutation
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer"
DOI: 10.1186/s12943-025-02247-4
Abstract: The mutation in Gsα-coding GNAS exons, popular as gsp oncogene, is the most frequent mutation across all heterotrimeric G proteins involved in oncogenesis. GNAS R201, the most frequently mutated, followed by Q227, are found predominantly… read more here.
Keywords: gnas mutation; contract kill; mutation; kill gnas ... See more keywords