Hyperglycemia-induced cardiac contractile dysfunction in the diabetic heart
Sign Up to like & getrecommendations! Published in 2017 at "Heart Failure Reviews"
DOI: 10.1007/s10741-017-9663-y
Abstract: The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart… read more here.
Keywords: heart; dysfunction diabetic; diabetic heart; contractile dysfunction ... See more keywords
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis
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DOI: 10.1016/j.molmet.2021.101293
Abstract: Objective The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal/lysosomal proton pump). Specifically, lipid… read more here.
Keywords: heart; contractile; atpase; contractile dysfunction ... See more keywords
The IGF-1R Inhibitor NVP-AEW541 Causes Insulin-Independent and Reversible Cardiac Contractile Dysfunction
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DOI: 10.3390/biomedicines10082022
Abstract: The antitumor treatment NVP-AEW541 blocks IGF-1R. IGF-1R signaling is crucial for cardiac function, but the cardiac effects of NVP-AEW541 are ill defined. We assessed NVP-AEW541′s effects on cardiac function and insulin response in vivo and… read more here.
Keywords: function; contractile dysfunction; aew541; nvp aew541 ... See more keywords