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   Articles with "contractile dysfunction" as a keyword



Hyperglycemia-induced cardiac contractile dysfunction in the diabetic heart

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recommendations! Published in 2017 at "Heart Failure Reviews"

DOI: 10.1007/s10741-017-9663-y

Abstract: The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart… read more here.

Keywords: heart; dysfunction diabetic; diabetic heart; contractile dysfunction ... See more keywords
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Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

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recommendations! Published in 2021 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2021.101293

Abstract: Objective The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal/lysosomal proton pump). Specifically, lipid… read more here.

Keywords: heart; contractile; atpase; contractile dysfunction ... See more keywords

Abstract 4145905: NLRP3 signaling in rodent and human right ventricular failure is sexually dimorphic and regulated by 17β-estradiol via estrogen receptor α

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recommendations! Published in 2024 at "Circulation"

DOI: 10.1161/circ.150.suppl_1.4145905

Abstract: Introduction: Estrogen receptor α (ERα) promotes cardioprotective signaling in right ventricle cardiomyocytes (RVCMs). NLRP3 inflammasome activation in macrophages contributes to RV failure (RVF) development in pulmonary hypertension (PH). However, NLRP3 signaling in RVCMs has not… read more here.

Keywords: male female; activation; contractile dysfunction; ipsc cms ... See more keywords

Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity

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recommendations! Published in 2024 at "JCI Insight"

DOI: 10.1172/jci.insight.175047

Abstract: Pulmonary disorders affect 40%–80% of individuals with obesity. Respiratory muscle dysfunction is linked to these conditions; however, its pathophysiology remains largely undefined. Mice subjected to diet-induced obesity (DIO) develop diaphragm muscle weakness. Increased intradiaphragmatic adiposity… read more here.

Keywords: obesity; dysfunction; contractile dysfunction; diaphragm ... See more keywords

The IGF-1R Inhibitor NVP-AEW541 Causes Insulin-Independent and Reversible Cardiac Contractile Dysfunction

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recommendations! Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10082022

Abstract: The antitumor treatment NVP-AEW541 blocks IGF-1R. IGF-1R signaling is crucial for cardiac function, but the cardiac effects of NVP-AEW541 are ill defined. We assessed NVP-AEW541′s effects on cardiac function and insulin response in vivo and… read more here.

Keywords: function; contractile dysfunction; aew541; nvp aew541 ... See more keywords