MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.11.011
Abstract: OBJECTIVE Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells and osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor in the development of OA. Mitofusin… read more here.
Keywords: mfn2; mfn2 contributes; metabolic disorders; rat chondrocytes ... See more keywords
Cellular senescence in hepatocytes contributes to metabolic disturbances in NASH
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.957616
Abstract: Cellular senescence is a state of irreversible cell cycle arrest and has been shown to play a key role in many diseases, including metabolic diseases. To investigate the potential contribution of hepatocyte cellular senescence to… read more here.
Keywords: hepatocytes contributes; senescence hepatocytes; metabolic disturbances; senescence ... See more keywords