Genetic and functional analysis reveals TENM4 contributes to schizophrenia
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DOI: 10.1016/j.isci.2021.103063
Abstract: Summary TENM4, encoding a member of the teneurin protein family, is a risk gene shared by many types of mental diseases and is implicated in neuronal plasticity and signaling. However, the role and the mechanisms… read more here.
Keywords: analysis reveals; tenm4 contributes; genetic functional; contributes schizophrenia ... See more keywords
KCTD10 p.C124W variant contributes to schizophrenia by attenuating LLPS-mediated synapse formation
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DOI: 10.1073/pnas.2400464121
Abstract: Significance Our study introduces the potential association between liquid–liquid phase separation (LLPS) disruptions and schizophrenia-like behaviors, mediated by KCTD10. We demonstrate that a de novo mutation, p.C124W, in KCTD10 compromises its LLPS capability and ability… read more here.
Keywords: kctd10 c124w; schizophrenia attenuating; contributes schizophrenia; c124w variant ... See more keywords