Prediction of the Contribution Ratio of a Target Metabolic Enzyme to Clearance from Chemical Structure Information.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00698
Abstract: The contribution ratio of metabolic enzymes such as cytochrome P450 to in vivo clearance (fraction metabolized: fm) is a pharmacokinetic index that is particularly important for the quantitative evaluation of drug-drug interactions. Since obtaining experimental… read more here.
Keywords: information; structure information; vivo values; chemical structure ... See more keywords
Contribution Ratio Assessment of Process Parameters on Robotic Milling Performance
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15103566
Abstract: Robotic milling has broad application prospects in many processing fields. However, the milling performance of a robot in a certain posture, such as in face milling or grooving tasks, is extremely sensitive to process parameters… read more here.
Keywords: process parameters; contribution ratio; milling; milling performance ... See more keywords