Analysis of Control Arm Quality in Randomized Clinical Trials Leading to Anticancer Drug Approval by the US Food and Drug Administration.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.0167
Abstract: Importance To date, an empirical evaluation of the quality of control arms in randomized clinical trials (RCTs) leading to anticancer drug approvals by the US Food and Drug Administration (FDA) has not been undertaken. Objective… read more here.
Keywords: quality; control; anticancer drug; arm ... See more keywords
A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51774
Abstract: OBJECTIVE Phosphodiesterase-5 inhibitors (PDE5Is) enhance vasodilation. We investigated the effects of PDE5I on cerebral hemodynamics during cognitive tasks using functional near-infrared spectroscopy (fNIRS). METHODS This study used a crossover design. Twelve cognitively healthy men participants… read more here.
Keywords: cerebral hemodynamics; control arm; cortex; hemodynamics ... See more keywords
Maternal participation on preterm infants care reduces the cost of delivery of preterm neonatal healthcare services
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neonatal Nursing"
DOI: 10.1016/j.jnn.2020.03.005
Abstract: Abstract Background Thailand, with an annual incidence rate of 12% ranks high in incidence of preterm birth. Preterm infants require specialized care which can be lengthy and costly both in terms of psychological and emotional… read more here.
Keywords: healthcare services; mpp arm; preterm infants; arm ... See more keywords
September ECI biocommentary
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Research"
DOI: 10.1038/s41390-018-0106-9
Abstract: I am a Pharmacologist and Certified Clinical Research Professional who grew up in Toronto, Canada. I completed an undergraduate degree in Medical Sciences at Western University, where I quickly became fascinated by how drugs worked… read more here.
Keywords: research; pain management; september eci; september ... See more keywords
Effects of a Novel Erectogenic Condom on Men and Women's Sexual Pleasure: Randomized Controlled Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of sex research"
DOI: 10.1080/00224499.2021.2024790
Abstract: We tested whether CSD500 (Futura Medical; Guildford, UK), a novel condom containing erectogenic gel designed to increase penile firmness, penile size, and erection duration, results in greater sexual pleasure. In 2017-2020, we randomized heterosexual couples… read more here.
Keywords: control arm; sexual pleasure; sex; men csd500 ... See more keywords
Matching design for augmenting the control arm of a randomized controlled trial using real-world data.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2021.2011900
Abstract: Randomized clinical trials (RCTs) have often been considered as the gold standard in drug development, but they may not be fully powered due to limited patient population and can even lead to ethical concerns in… read more here.
Keywords: control arm; world data; trial; real world ... See more keywords
Blood eosinophils, fractional exhaled nitric oxide and the risk of asthma attacks in randomised controlled trials: protocol for a systemic review and control arm patient-level meta-analysis for clinical prediction modelling
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-058215
Abstract: Introduction The reduction of the risk of asthma attacks is a major goal of guidelines. The fact that type-2 inflammatory biomarkers identify a higher risk, anti-inflammatory responsive phenotype is potentially relevant to this goal. We… read more here.
Keywords: asthma attacks; risk; blood eosinophils; control arm ... See more keywords
Forming analysis and process study for a 6082 aluminum alloy automobile control arm in the process of forging
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science"
DOI: 10.1177/09544062221087550
Abstract: To reduce the weight of vehicles and save on fuel consumption, the forming analysis and process study for a 6082 aluminum alloy automobile control arm were conducted, and the results are reported here. First, the… read more here.
Keywords: control arm; aluminum alloy; control; process ... See more keywords
Investigation of the buckling behavior of a control arm with Si particle reinforced aluminum based metal composite material
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering"
DOI: 10.1177/09544070211070948
Abstract: Control arms are subjected to static and dynamic loads in car during their lifetime. Recent increases in loads in which control arms are subjected, are not complying with the low-weight design targets expected by auto… read more here.
Keywords: buckling behavior; control arm; aluminum; control arms ... See more keywords
Building External Control Arms From Patient-Level Electronic Health Record Data to Replicate the Randomized IMblaze370 Control Arm in Metastatic Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "JCO Clinical Cancer Informatics"
DOI: 10.1200/cci.20.00149
Abstract: PURPOSE External control (EC) arms derived from electronic health records (EHRs) can provide appropriate comparison groups when randomized control arms are not feasible, but have not been explored for metastatic colorectal cancer (mCRC) trials. We… read more here.
Keywords: control arm; health; control; control arms ... See more keywords
Effectiveness of Group Problem Management Plus, a brief psychological intervention for adults affected by humanitarian disasters in Nepal: A cluster randomized controlled trial
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Medicine"
DOI: 10.1371/journal.pmed.1003621
Abstract: Background Globally, 235 million people are impacted by humanitarian emergencies worldwide, presenting increased risk of experiencing a mental disorder. Our objective was to test the effectiveness of a brief group psychological treatment delivered by trained… read more here.
Keywords: treatment; group; arm wards; arm ... See more keywords