Utilizing shared internal control arms and historical information in small-sized platform clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2019.1657132
Abstract: ABSTRACT Recruitment of patients in concurrent control arms can be very challenging for clinical trials for pediatric and rare diseases. Innovative approaches, such as platform trial designs, including shared internal control arm(s), can potentially reduce… read more here.
Keywords: information; shared internal; control; clinical trials ... See more keywords
Exploring the Potential of External Control Arms created from Patient Level Data: A case study in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2021.2011901
Abstract: ABSTRACT Randomized controlled trials (RCTs) are the gold standard for evaluation of new medical products. However, RCTs may not always be ethical or feasible. In cases where the investigational product is available outside the trial… read more here.
Keywords: case study; external control; control arms; control ... See more keywords
Investigation of the buckling behavior of a control arm with Si particle reinforced aluminum based metal composite material
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering"
DOI: 10.1177/09544070211070948
Abstract: Control arms are subjected to static and dynamic loads in car during their lifetime. Recent increases in loads in which control arms are subjected, are not complying with the low-weight design targets expected by auto… read more here.
Keywords: buckling behavior; control arm; aluminum; control arms ... See more keywords
Building External Control Arms From Patient-Level Electronic Health Record Data to Replicate the Randomized IMblaze370 Control Arm in Metastatic Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "JCO Clinical Cancer Informatics"
DOI: 10.1200/cci.20.00149
Abstract: PURPOSE External control (EC) arms derived from electronic health records (EHRs) can provide appropriate comparison groups when randomized control arms are not feasible, but have not been explored for metastatic colorectal cancer (mCRC) trials. We… read more here.
Keywords: control arm; health; control; control arms ... See more keywords
Obesity and metastatic castration resistant prostate cancer: Results from the control arms of ASCENT2, MAINSAL and VENICE trials.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.7_suppl.287
Abstract: 287 Background: Previous findings regarding the correlation between body mass index (BMI) and survival in patients with prostate cancer are conflicting and may be disease-state dependent. We aimed to test whether BMI among patients with… read more here.
Keywords: obesity; cancer; control arms; prostate cancer ... See more keywords