Control of gene expression in engineered mammalian cells with a programmable shear-stress inducer.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27939
Abstract: In humans, cellular mechanoperception serves as the basis of touch sensation and proprioception, contributes to the proper programming of cell fate during embryonic development, and plays a pivotal role in the development of mechanosensitive tissues.… read more here.
Keywords: control gene; gene; shear stress; gene expression ... See more keywords
Using Morpholinos to Control Gene Expression
Sign Up to like & getrecommendations! Published in 2017 at "Current Protocols in Nucleic Acid Chemistry"
DOI: 10.1002/cpnc.21
Abstract: Morpholino oligonucleotides are stable, uncharged, water‐soluble molecules used to block complementary sequences of RNA, preventing processing, read‐through, or protein binding at those sites. Morpholinos are typically used to block translation of mRNA and to block… read more here.
Keywords: block; using morpholinos; morpholinos control; chemistry ... See more keywords
Spatiotemporal control of gene expression boundaries using a feedforward loop
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.150
Abstract: A feedforward loop (FFL) is commonly observed in several biological networks. The FFL network motif has been mostly studied with respect to variation of the input signal in time, with only a few studies of… read more here.
Keywords: boundaries using; expression boundaries; gene expression; spatiotemporal control ... See more keywords
Mathematical Modeling of RNA-Based Architectures for Closed Loop Control of Gene Expression.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00040
Abstract: Feedback allows biological systems to control gene expression precisely and reliably, even in the presence of uncertainty, by sensing and processing environmental changes. Taking inspiration from natural architectures, synthetic biologists have engineered feedback loops to… read more here.
Keywords: control gene; control; feedback; gene expression ... See more keywords
CRISPRi-mediated tunable control of gene expression level with engineered single-guide RNA in Escherichia coli
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad234
Abstract: Abstract Precise control of gene expression is essential for flux redistribution in metabolic pathways. Although the CRISPR interference (CRISPRi) system can effectively repress gene expression at the transcriptional level, it has still been difficult to… read more here.
Keywords: crispri; level; gene expression; gene ... See more keywords
Control of Gene Regulatory Networks With Noisy Measurements and Uncertain Inputs
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Control of Network Systems"
DOI: 10.1109/tcns.2017.2746341
Abstract: This paper is concerned with the problem of stochastic control of gene regulatory networks (GRNs) observed indirectly through noisy measurements and with uncertainty in the intervention inputs. The partial observability of the gene states and… read more here.
Keywords: noisy measurements; regulatory networks; control; gene regulatory ... See more keywords
A toolbox for conditional control of gene expression in apicomplexan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular microbiology"
DOI: 10.1111/mmi.14821
Abstract: Apicomplexan parasites encompass diverse pathogens for humans and animals, including the causative agents of malaria and toxoplasmosis, Plasmodium spp. and Toxoplasma gondii. Genetic manipulation of these parasites has become central to explore parasite biology, unravel… read more here.
Keywords: conditional control; gene expression; expression; control gene ... See more keywords