The relation of blood cell division control protein 42 level with disease risk, comorbidity, tumor features/markers, and prognosis in colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24572
Abstract: Cell division control protein 42 (CDC42) is involved in colorectal cancer (CRC) progression by modulating CD8+ T cell activation, immune escape, and direct oncogenetic biological processes. This study aimed to explore the correlation of blood… read more here.
Keywords: cell; cell division; control protein; disease risk ... See more keywords
Engineering genetically-encoded tools for optogenetic control of protein activity.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.05.001
Abstract: Optogenetic tools offer fast and reversible control of protein activity with subcellular spatial precision. In the past few years, remarkable progress has been made in engineering photoactivatable systems regulating the activity of cellular proteins. In… read more here.
Keywords: control protein; protein activity; activity; engineering ... See more keywords
Blue Light Activated Rapamycin for Optical Control of Protein Dimerization in Cells and Zebrafish Embryos.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00547
Abstract: Rapamycin-induced dimerization of FKBP and FRB is the most commonly utilized chemically induced protein dimerization system. It has been extensively used to conditionally control protein localization, split-enzyme activity, and protein-protein interactions in general by simply… read more here.
Keywords: protein; blue light; control protein; dimerization ... See more keywords
Identification of a novel inhibitor of catabolite control protein A from Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00465
Abstract: Catabolite control protein A is a highly conserved transcriptional regulator in Gram-positive bacteria. Herein, we report a specific small-molecule inhibitor of Staphylococcus aureus CcpA (SaCcpA). The compound abrogates the regulatory function of SaCcpA, resulting in… read more here.
Keywords: control protein; catabolite control; staphylococcus aureus; inhibitor ... See more keywords
Spatially conserved motifs in complement control protein domains determine functionality in regulators of complement activation-family proteins
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0529-9
Abstract: Regulation of complement activation in the host cells is mediated primarily by the regulators of complement activation (RCA) family proteins that are formed by tandemly repeating complement control protein (CCP) domains. Functional annotation of these… read more here.
Keywords: control protein; complement control; regulators complement; complement ... See more keywords
Optical control of protein delivery and partitioning in the nucleolus
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac191
Abstract: Abstract The nucleolus is a subnuclear membraneless compartment intimately involved in ribosomal RNA synthesis, ribosome biogenesis and stress response. Multiple optogenetic devices have been developed to manipulate nuclear protein import and export, but molecular tools… read more here.
Keywords: protein delivery; control; control protein; optical control ... See more keywords
PHOTACs enable optical control of protein degradation
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay5064
Abstract: We present a modular approach to control the small molecule–mediated degradation of cellular proteins of interest using light. PROTACs (PROteolysis TArgeting Chimeras) are bifunctional molecules that target proteins for ubiquitylation by an E3 ligase complex… read more here.
Keywords: control protein; degradation; photacs enable; control ... See more keywords
Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1195558
Abstract: In the opportunistic human pathogen Pseudomonas aeruginosa (Pae), carbon catabolite repression (CCR) orchestrates the hierarchical utilization of N and C sources, and impacts virulence, antibiotic resistance and biofilm development. During CCR, the RNA chaperone Hfq… read more here.
Keywords: carbon; repression control; catabolite repression; repression ... See more keywords