Intravenous infusion for the controlled exposure to the dual ABCB1 and ABCG2 inhibitor elacridar in nonhuman primates
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-017-0472-6
Abstract: Elacridar (GF120918) is a highly potent inhibitor of both P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2), the main efflux transporters expressed at the blood-brain barrier (BBB). Elacridar shows very low aqueous solubility, which complicates… read more here.
Keywords: controlled exposure; elacridar; infusion; intravenous infusion ... See more keywords
Ozone exposure and prothrombosis: Mechanistic insights from a randomized controlled exposure trial.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2022.128322
Abstract: Epidemiological studies have associated ozone exposure with cardiovascular diseases, but the molecular mechanisms were not elucidated. We performed an untargeted serum proteomic analysis in a randomized, crossover, controlled exposure trial. We recruited 32 healthy young… read more here.
Keywords: exposure; ozone exposure; controlled exposure; ozone ... See more keywords
59 First-in-Human Controlled Exposure to Inhaled Graphene Oxide
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Work Exposures and Health"
DOI: 10.1093/annweh/wxac087.128
Abstract: Graphene oxide nanomaterials have been developed for wide-ranging applications, but has potential safety concerns for human health. Controlled inhalation exposures in human volunteers have been a vital means to determine the effects and mechanisms of… read more here.
Keywords: graphene; controlled exposure; human controlled; graphene oxide ... See more keywords
Does Ambient Ozone or Other Pollutants Modify Effects of Controlled Ozone Exposure on Pulmonary Function?
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the American Thoracic Society"
DOI: 10.1513/annalsats.201908-597oc
Abstract: RATIONALE Previously, in the Multi-center Ozone Study of oldEr Subjects (MOSES), 3 hours of controlled ozone (O3) exposure caused concentration-related reductions in lung function with evidence for airway inflammation and injury, but without convincing evidence… read more here.
Keywords: controlled exposure; ozone exposure; controlled ozone; exposure ... See more keywords