Adaptation of vectors and drug‐inducible systems for controlled expression of transgenes in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.10.032
Abstract: &NA; Biological therapies based on recombinant proteins such as antibodies or cytokines are continuously improving the repertoire of treatments against cancer. However, safety and efficacy of this approach is often limited by inappropriate biodistribution and… read more here.
Keywords: vector; administration; controlled expression; drug ... See more keywords
A Ubiquitous Chromatin Opening Element and DNA Demethylation Facilitate Doxycycline-Controlled Expression during Differentiation and in Transgenic Mice
Sign Up to like & getrecommendations! Published in 2023 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00450
Abstract: Synthetic expression cassettes provide the ability to control transgene expression in experimental animal models through external triggers, enabling the study of gene function and the modulation of endogenous regulatory networks in vivo. The performance of… read more here.
Keywords: doxycycline controlled; doxycycline; cbx3; controlled expression ... See more keywords
Controlled Over-Expression of AtDREB1A Enhances Tolerance against Drought and Salinity in Rice
Sign Up to like & getrecommendations! Published in 2021 at "Agronomy"
DOI: 10.3390/agronomy11010159
Abstract: Engineering transcription factors (TF) hold promise in enhancing abiotic stress tolerance in plants. In this study, one of the popular rice varieties of South India, namely ADT 43, was engineered with a TF AtDREB1A driven… read more here.
Keywords: drought salinity; non transgenic; tolerance; tolerance drought ... See more keywords