Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.
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DOI: 10.1007/s00204-021-03177-y
Abstract: The pregnane X receptor (PXR) is a ligand-activated nuclear receptor controlling hepatocyte expression of numerous genes. Although expression changes in xenobiotic-metabolizing, lipogenic, gluconeogenic and bile acid synthetic genes have been described after PXR activation, the… read more here.
Keywords: controlled genes; expression; pxr; receptor ... See more keywords
Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding
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DOI: 10.1134/s1607672919050016
Abstract: The interaction of the GAF protein with the promoters of neuron-specific genes during activation and repression of transcription was studied. We showed that, while the Su(Hw) protein remains stably associated with the promoters of these… read more here.
Keywords: activation; activation controlled; gaf; associated increase ... See more keywords