Controlled Human Malaria Infection (CHMI) Studies: Over 100 Years of Experience with Parasite Injections.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9550-9_7
Abstract: Human experimentation by deliberate infection with malarial parasites seems unethical yet has a long history in infectious disease research. After rigorous screening, volunteers are inoculated with Plasmodium sporozoites or blood stages and monitored under strict… read more here.
Keywords: controlled human; infection; malaria infection; chmi studies ... See more keywords
Controlled human infection with RSV: The opportunities of experimental challenge.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.08.086
Abstract: Despite the recent explosion in RSV vaccine development, there remain substantial hurdles to overcome before licensing of effective vaccines will allow widespread use, particularly in high-risk populations. Incomplete understanding of mechanisms and correlates of protection… read more here.
Keywords: human infection; challenge; controlled human; infection ... See more keywords
Glycan-Controlled Human PD-1 Variants Displaying Broad-Spectrum High Binding to PD-1 Ligands Potentiate T Cell.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00003
Abstract: Although therapeutic immunoglobulin G (IgG) antibodies that regulate the activity of immune checkpoints bring innovation to the field of immuno-oncology, they are still limited in their efficiency to infiltrate the tumor microenvironment due to their… read more here.
Keywords: hpd; high binding; glycan controlled; controlled human ... See more keywords
Ethics of controlled human infection to address COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abc1076
Abstract: High social value is fundamental to justifying these studies Development of an effective vaccine is the clearest path to controlling the coronavirus disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some researchers are pursuing, and… read more here.
Keywords: human infection; controlled human; infection; social value ... See more keywords
Controlled Human Infection Models To Accelerate Vaccine Development
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Microbiology Reviews"
DOI: 10.1128/cmr.00008-21
Abstract: The timelines for developing vaccines against infectious diseases are lengthy, and often vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of protective efficacy. The application of… read more here.
Keywords: controlled human; development; infection; human challenge ... See more keywords
Controlled human infection with Neisseria lactamica in late pregnancy to measure horizontal transmission and microbiome changes in mother–neonate pairs: a single-arm interventional pilot study protocol
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-056081
Abstract: Introduction Infant upper respiratory microbiota are derived partly from the maternal respiratory tract, and certain microbiota are associated with altered risk of infections and respiratory disease. Neisseria lactamica is a common pharyngeal commensal in young… read more here.
Keywords: human infection; controlled human; nasal inoculation; microbiome ... See more keywords
Controlled human infection with SARS-CoV-2 to study COVID-19 vaccines and treatments: bioethics in Utopia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2020-106476
Abstract: A number of papers have appeared recently arguing for the conclusion that it is ethically acceptable to infect healthy volunteers with severe acute respiratory syndrome coronavirus 2 as part of research projects aimed at developing… read more here.
Keywords: vaccines treatments; human infection; covid vaccines; research ... See more keywords
COVID-19 controlled human infection studies: worries about local community impact and demands for local engagement
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2021-107229
Abstract: In spring, summer and autumn 2020, one abiding argument against controlled human infection (CHI) studies of SARS-CoV-2 vaccines has been their impact on local communities. Leading scientists and bioethicists expressed concern about undue usage of… read more here.
Keywords: local community; human infection; controlled human; infection ... See more keywords
Controlled human malaria infection with a clone of Plasmodium vivax with high quality genome assembly.
Sign Up to like & getrecommendations! Published in 2021 at "JCI insight"
DOI: 10.1172/jci.insight.152465
Abstract: Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-characterized P. vivax parasites that… read more here.
Keywords: controlled human; high quality; quality genome; vivax ... See more keywords
Controlled human exposures to wood smoke: a synthesis of the evidence
Sign Up to like & getrecommendations! Published in 2020 at "Particle and Fibre Toxicology"
DOI: 10.1186/s12989-020-00375-x
Abstract: Background Exposure to particulate matter (PM) from wood combustion represents a global health risk, encompassing diverse exposure sources; indoor exposures due to cooking in developing countries, ambient PM exposures from residential wood combustion in developed… read more here.
Keywords: exposure levels; controlled human; wood smoke; exposure ... See more keywords
Perceptions about controlled human infection model (CHIM) studies among members of ethics committees of Indian medical institutions: A qualitative exploration.
Sign Up to like & getrecommendations! Published in 2022 at "Wellcome open research"
DOI: 10.12688/wellcomeopenres.17968.2
Abstract: Introduction: Controlled Human Infection Model (CHIM) studies provide a unique platform for studying the pathophysiology of infectious diseases and accelerated testing of vaccines and drugs in controlled settings. However, ethical issues shroud them as the… read more here.
Keywords: ethics committees; infection model; human infection; controlled human ... See more keywords