Controlled Human Malaria Infection (CHMI) Studies: Over 100 Years of Experience with Parasite Injections.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9550-9_7
Abstract: Human experimentation by deliberate infection with malarial parasites seems unethical yet has a long history in infectious disease research. After rigorous screening, volunteers are inoculated with Plasmodium sporozoites or blood stages and monitored under strict… read more here.
Keywords: controlled human; infection; malaria infection; chmi studies ... See more keywords
Controlled human infection with RSV: The opportunities of experimental challenge.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.08.086
Abstract: Despite the recent explosion in RSV vaccine development, there remain substantial hurdles to overcome before licensing of effective vaccines will allow widespread use, particularly in high-risk populations. Incomplete understanding of mechanisms and correlates of protection… read more here.
Keywords: human infection; challenge; controlled human; infection ... See more keywords
Glycan-Controlled Human PD-1 Variants Displaying Broad-Spectrum High Binding to PD-1 Ligands Potentiate T Cell.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00003
Abstract: Although therapeutic immunoglobulin G (IgG) antibodies that regulate the activity of immune checkpoints bring innovation to the field of immuno-oncology, they are still limited in their efficiency to infiltrate the tumor microenvironment due to their… read more here.
Keywords: hpd; high binding; glycan controlled; controlled human ... See more keywords
T cell responses in repeated controlled human schistosome infection compared to natural exposure
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DOI: 10.1038/s41467-025-62144-8
Abstract: In Schistosoma-endemic regions a lack of natural sterilizing immunity means individuals are repeatedly infected, treated and reinfected. Due to difficulties in tracking natural infection, kinetics of host immune response during these reinfections have not been… read more here.
Keywords: repeated controlled; responses repeated; schistosome infection; cell ... See more keywords
Ethics of controlled human infection to address COVID-19
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DOI: 10.1126/science.abc1076
Abstract: High social value is fundamental to justifying these studies Development of an effective vaccine is the clearest path to controlling the coronavirus disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some researchers are pursuing, and… read more here.
Keywords: human infection; controlled human; infection; social value ... See more keywords
Controlled Human Infection Models To Accelerate Vaccine Development
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DOI: 10.1128/cmr.00008-21
Abstract: The timelines for developing vaccines against infectious diseases are lengthy, and often vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of protective efficacy. The application of… read more here.
Keywords: controlled human; development; infection; human challenge ... See more keywords
Controlled human infection with Neisseria lactamica in late pregnancy to measure horizontal transmission and microbiome changes in mother–neonate pairs: a single-arm interventional pilot study protocol
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-056081
Abstract: Introduction Infant upper respiratory microbiota are derived partly from the maternal respiratory tract, and certain microbiota are associated with altered risk of infections and respiratory disease. Neisseria lactamica is a common pharyngeal commensal in young… read more here.
Keywords: human infection; controlled human; nasal inoculation; microbiome ... See more keywords
An analysis of controlled human infection studies registered on ClinicalTrials.gov
Sign Up to like & getrecommendations! Published in 2024 at "BMJ Open"
DOI: 10.1136/bmjopen-2024-085250
Abstract: Objectives Controlled human infection studies (CHIS) involve intentional exposure of human volunteers to infectious agents. A previous systematic review found that adverse event (AE) reporting across CHIS is inconsistent, which makes data aggregation and reuse… read more here.
Keywords: infection studies; clinical trial; clinicaltrials gov; analysis ... See more keywords
Controlled human infection with SARS-CoV-2 to study COVID-19 vaccines and treatments: bioethics in Utopia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2020-106476
Abstract: A number of papers have appeared recently arguing for the conclusion that it is ethically acceptable to infect healthy volunteers with severe acute respiratory syndrome coronavirus 2 as part of research projects aimed at developing… read more here.
Keywords: vaccines treatments; human infection; covid vaccines; research ... See more keywords
COVID-19 controlled human infection studies: worries about local community impact and demands for local engagement
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2021-107229
Abstract: In spring, summer and autumn 2020, one abiding argument against controlled human infection (CHI) studies of SARS-CoV-2 vaccines has been their impact on local communities. Leading scientists and bioethicists expressed concern about undue usage of… read more here.
Keywords: local community; human infection; controlled human; infection ... See more keywords
Controlled human malaria infection with a clone of Plasmodium vivax with high quality genome assembly.
Sign Up to like & getrecommendations! Published in 2021 at "JCI insight"
DOI: 10.1172/jci.insight.152465
Abstract: Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-characterized P. vivax parasites that… read more here.
Keywords: controlled human; high quality; quality genome; vivax ... See more keywords