A stereoselective construction of a cis-1,2-oxazadecaline skeleton using a substrate-controlled intramolecular oxy-Michael addition of tyrosine-derived hydroxylamines
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DOI: 10.1016/j.tetlet.2019.151412
Abstract: Abstract A method for the stereoselective construction of cis-1,2-oxazadecaline skeletons via a substrate-controlled intramolecular oxy-Michael addition of readily available tyrosine-derived hydroxylamines has been developed. The approach features an eight-step synthesis of the optically active cis-1,2-oxazadecaline… read more here.
Keywords: cis; substrate controlled; controlled intramolecular; cis oxazadecaline ... See more keywords
Steric- and Electronic-Controlled Intramolecular [2 + 2]-Cycloaddition of Cyclohexadienone-Containing 1,7-Enynes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04232
Abstract: Herein we have developed the silver-catalyzed electronic- and steric-controlled intramolecular formal [2 + 2]-cycloaddition of alkyne-tethered cyclohexadienones. Substrates with electron-rich alkynes and a less hindered quaternary carbon center afford tricyclic fused cyclobutenes through 1,7-enyne cyclization.… read more here.
Keywords: controlled intramolecular; electronic controlled; intramolecular cycloaddition; steric electronic ... See more keywords