Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-Dose and Multiple-Dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2021.04.014
Abstract: PURPOSE For neuropathic pain, current therapies do not provide relief for most patients; less than half achieve a 50% pain reduction. Current analgesics have adverse effects. We present 2 Phase I studies of LX9211, a… read more here.
Keywords: lx9211; controlled studies; placebo controlled; multiple dose ... See more keywords
From single-arm studies to externally controlled studies. Methodological considerations and guidelines.
Sign Up to like & getrecommendations! Published in 2019 at "Therapie"
DOI: 10.1016/j.therap.2019.11.007
Abstract: Single-arm studies are sometimes used as pivotal studies but they have methodological limitations which prevent them from obtaining the high level of reliability as for a randomised controlled study which remains the gold standard in… read more here.
Keywords: controlled studies; externally controlled; arm studies; single arm ... See more keywords
Role of rituximab in the treatment of systemic sclerosis: A literature review.
Sign Up to like & getrecommendations! Published in 2023 at "Modern rheumatology"
DOI: 10.1093/mr/road040
Abstract: OBJECTIVES To evaluate the effectiveness of rituximab (RTX) in patients with systemic sclerosis (SSc). METHODS PubMed was searched for articles, published through March 31, 2022, on any controlled studies using RTX in the treatment of… read more here.
Keywords: systemic sclerosis; controlled studies; patients ssc; treatment ... See more keywords
Specific immunotherapy in renal cancer: a systematic review
Sign Up to like & getrecommendations! Published in 2017 at "Therapeutic Advances in Urology"
DOI: 10.1177/1756287216681246
Abstract: Background: Renal cell cancer (RCC) is the tenth most common malignancy in adults. In recent years, several approaches of active and passive immunotherapy have been studied extensively in clinical trials of patients with RCC. The… read more here.
Keywords: controlled studies; systematic review; patients rcc; review ... See more keywords
Functioning outcomes with adjunctive treatments for major depressive disorder: a systematic review of randomized placebo-controlled studies
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s146840
Abstract: Objective Patients with major depressive disorder (MDD) with inadequate response to antidepressant treatment (ADT) may suffer a prolonged loss of functioning. This review aimed to determine if self-rated functional measures are informative in randomized placebo-controlled… read more here.
Keywords: controlled studies; placebo controlled; major depressive; randomized placebo ... See more keywords