Health‐related quality of life in stage III‐IV melanoma treated with targeted therapy or immunotherapy: A systematic review on the adequacy of reporting and clinical issues in phase III randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5183
Abstract: Cutaneous melanoma represents around over 90% of all melanoma. With more effective treatments able to extend patients' survival, health‐related quality of life (HRQOL) is increasingly becoming an important endpoint in cancer clinical trials. They are… read more here.
Keywords: iii randomized; randomized controlled; controlled trials; hrqol ... See more keywords
Patent foramen ovale (PFO) closure versus medical therapy for prevention of recurrent stroke in patients with prior cryptogenic stroke: A systematic review and meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.27615
Abstract: We performed a systematic review and meta‐analysis of randomized controlled trials to assess the effect of closure of a patent foramen ovale (PFO) compared with medical therapy for the prevention of stroke in patients with… read more here.
Keywords: randomized controlled; review meta; systematic review; analysis randomized ... See more keywords
Randomized Controlled Trials Versus Real World Evidence: Neither Magic Nor Myth
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2083
Abstract: Compared with drugs from the blockbuster era, recently authorized drugs and those expected in the future present a heterogenous mix of chemicals, biologicals, and cell and gene therapies, a sizable fraction being for rare diseases,… read more here.
Keywords: real world; world evidence; randomized controlled; evidence ... See more keywords
Medline indexing of the latest research findings in dental research has stopped
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.103
Abstract: The US National Library of Medicine (NLM) and National Institutes of Health (NIH) manage Medline, considered the flagship bibliographic database of medical research publications. Something has happened because both straightforward and refined search strategies provide… read more here.
Keywords: research; search; dental research; medline ... See more keywords
Yoga for anxiety: A systematic review and meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "Depression and Anxiety"
DOI: 10.1002/da.22762
Abstract: Yoga has become a popular approach to improve emotional health. The aim of this review was to systematically assess and meta‐analyze the effectiveness and safety of yoga for anxiety. Medline/PubMed, Scopus, the Cochrane Library, PsycINFO,… read more here.
Keywords: randomized controlled; anxiety; review; yoga anxiety ... See more keywords
Probiotics for the treatment of type 2 diabetes: A review of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3213
Abstract: With the increasing prevalence of type 2 diabetes mellitus (T2DM), there is increased interest in probiotic supplementation for improving glycaemic control. This review evaluates nine randomized controlled trials that tested the effects of probiotics on… read more here.
Keywords: treatment type; randomized controlled; type diabetes; probiotics treatment ... See more keywords
Improving clinical trial efficiency: Is technology the answer?
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia Open"
DOI: 10.1002/epi4.12042
Abstract: Adjunctive randomized placebo-controlled trials are the gold standard for determining whether new antiseizure drugs (ASDs) are effective for patients with treatmentresistant epilepsy. In these studies, patients receiving the novel ASD as an add-on are compared… read more here.
Keywords: medicine; trial; seizure; controlled trials ... See more keywords
The Emperor's New Clothes: What Randomized Controlled Trials Don't Cover
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3539
Abstract: Randomized controlled trials are the bedrock of evidence-based medicine (EBM). They avoid the major pitfalls of anecdotal evidence, conscious and unconscious bias in patient selection and outcome assessments. Randomized clinical trials (RCTs) have revolutionized our… read more here.
Keywords: clothes randomized; randomized controlled; emperor new; new clothes ... See more keywords
Direct Oral Anticoagulation versus Warfarin in Left Ventricular Thrombus: Pooled Analysis of Randomized Controlled Trials.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2267
Abstract: Patients with impaired left ventricular (LV) function can develop LV thrombus, a potentially life-threatening condition due to risk of stroke and embolization. Conventional treatment with vitamin K antagonists (VKA; e.g., warfarin) puts patients at risk… read more here.
Keywords: randomized controlled; controlled trials; direct oral; thrombus ... See more keywords
Effect of azithromycin and hydroxychloroquine in patients hospitalized with COVID‐19: Network meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27259
Abstract: Chloroquine or its derivative hydroxychloroquine (HCQ) combined with or without azithromycin (AZ) have been widely investigated in observational studies as a treatment option for coronavirus 2019 (COVID‐19) infection. The network meta‐analysis aims to summarize evidence… read more here.
Keywords: hydroxychloroquine; randomized controlled; effect; network meta ... See more keywords
Efficacy of melatonin in the treatment of patients with COVID‐19: A systematic review and meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27595
Abstract: This study investigated the effect of melatonin on clinical outcomes in patients with coronavirus disease 2019 (COVID‐19). We searched PubMed, the Web of Science, the Cochrane Library, Ovid MEDLINE, and Clinicaltrials.gov for randomized controlled trials… read more here.
Keywords: efficacy melatonin; randomized controlled; controlled trials; treatment ... See more keywords