Design, Conduct, and Analysis of Externally Controlled Trials
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.30277
Abstract: Key Points Question How are externally controlled trials (ECTs) currently designed, conducted, and analyzed in practice, and do they use methods, such as statistical methods, to control bias? Findings In this cross-sectional analysis of 180… read more here.
Keywords: conduct analysis; controlled trials; externally controlled; analysis externally ... See more keywords
Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Neurology"
DOI: 10.1002/ana.70021
Abstract: The efficacy and safety of intra‐arterial thrombolysis (IAT) as an adjunct to endovascular thrombectomy (EVT) in large vessel occlusion strokes (LVOS) remain uncertain, with recent randomized controlled trials (RCTs) yielding conflicting results. This meta‐analysis aimed… read more here.
Keywords: meta analysis; controlled trials; adjunctive thrombolytics; randomized controlled ... See more keywords
Health‐related quality of life in stage III‐IV melanoma treated with targeted therapy or immunotherapy: A systematic review on the adequacy of reporting and clinical issues in phase III randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5183
Abstract: Cutaneous melanoma represents around over 90% of all melanoma. With more effective treatments able to extend patients' survival, health‐related quality of life (HRQOL) is increasingly becoming an important endpoint in cancer clinical trials. They are… read more here.
Keywords: iii randomized; randomized controlled; controlled trials; hrqol ... See more keywords
Patent foramen ovale (PFO) closure versus medical therapy for prevention of recurrent stroke in patients with prior cryptogenic stroke: A systematic review and meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.27615
Abstract: We performed a systematic review and meta‐analysis of randomized controlled trials to assess the effect of closure of a patent foramen ovale (PFO) compared with medical therapy for the prevention of stroke in patients with… read more here.
Keywords: randomized controlled; review meta; systematic review; analysis randomized ... See more keywords
Invasive Versus Conservative Strategies in Older Adults With Non‐ST Elevation Acute Coronary Syndrome: An Updated Meta‐Analysis of Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2025 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.31533
Abstract: Non‐ST‐elevation acute coronary syndrome (NSTE‐ACS) is a common condition among older adults. However, due to frailty and comorbidities, older adults are often underrepresented in clinical trials, making the decision between an invasive or conservative approach… read more here.
Keywords: meta analysis; non elevation; controlled trials; elevation acute ... See more keywords
Randomized Controlled Trials Versus Real World Evidence: Neither Magic Nor Myth
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2083
Abstract: Compared with drugs from the blockbuster era, recently authorized drugs and those expected in the future present a heterogenous mix of chemicals, biologicals, and cell and gene therapies, a sizable fraction being for rare diseases,… read more here.
Keywords: real world; world evidence; randomized controlled; evidence ... See more keywords
Medline indexing of the latest research findings in dental research has stopped
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.103
Abstract: The US National Library of Medicine (NLM) and National Institutes of Health (NIH) manage Medline, considered the flagship bibliographic database of medical research publications. Something has happened because both straightforward and refined search strategies provide… read more here.
Keywords: research; search; dental research; medline ... See more keywords
Yoga for anxiety: A systematic review and meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "Depression and Anxiety"
DOI: 10.1002/da.22762
Abstract: Yoga has become a popular approach to improve emotional health. The aim of this review was to systematically assess and meta‐analyze the effectiveness and safety of yoga for anxiety. Medline/PubMed, Scopus, the Cochrane Library, PsycINFO,… read more here.
Keywords: randomized controlled; anxiety; review; yoga anxiety ... See more keywords
Probiotics for the treatment of type 2 diabetes: A review of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3213
Abstract: With the increasing prevalence of type 2 diabetes mellitus (T2DM), there is increased interest in probiotic supplementation for improving glycaemic control. This review evaluates nine randomized controlled trials that tested the effects of probiotics on… read more here.
Keywords: treatment type; randomized controlled; type diabetes; probiotics treatment ... See more keywords
Improving clinical trial efficiency: Is technology the answer?
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia Open"
DOI: 10.1002/epi4.12042
Abstract: Adjunctive randomized placebo-controlled trials are the gold standard for determining whether new antiseizure drugs (ASDs) are effective for patients with treatmentresistant epilepsy. In these studies, patients receiving the novel ASD as an add-on are compared… read more here.
Keywords: medicine; trial; seizure; controlled trials ... See more keywords
The Emperor's New Clothes: What Randomized Controlled Trials Don't Cover
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3539
Abstract: Randomized controlled trials are the bedrock of evidence-based medicine (EBM). They avoid the major pitfalls of anecdotal evidence, conscious and unconscious bias in patient selection and outcome assessments. Randomized clinical trials (RCTs) have revolutionized our… read more here.
Keywords: clothes randomized; randomized controlled; emperor new; new clothes ... See more keywords