Cholesterol-Modified Oligonucleotides as Internal Reaction Controls during DNA-Encoded Chemical Library Synthesis.
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DOI: 10.1021/acs.bioconjchem.1c00045
Abstract: We report two cholesterol-modified oligonucleotides for use as internal controls for on-DNA reactions during the pooled stages of a DNA-encoded chemical library (DECL) synthesis. As these cholesterol-tagged oligonucleotides are chromatographically separable from normal DECL intermediates,… read more here.
Keywords: controls dna; cholesterol modified; modified oligonucleotides; cholesterol ... See more keywords
BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
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DOI: 10.1038/s41467-018-07799-2
Abstract: DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired, may lead to genomic instability, cell death and senescence. Damage-induced long non-coding RNAs (dilncRNAs) are transcribed from broken DNA ends and contribute… read more here.
Keywords: controls dna; dna; rnase; rna hybrid ... See more keywords