A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis.
Sign Up to like & getrecommendations! Published in 2021 at "Protein & cell"
DOI: 10.1007/s13238-021-00881-4
Abstract: Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not understood how the proper mitochondrial Zn2+ level is achieved to maintain mitochondrial homeostasis. Using… read more here.
Keywords: transporters controls; mitochondrial homeostasis; maintain mitochondrial; mitochondrial zn2 ... See more keywords
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.08.013
Abstract: The mechanisms that link environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well understood. Here, we demonstrate that the nutrient-sensing mechanistic/mammalian target of rapamycin complex 1… read more here.
Keywords: mtfp1; cell survival; fission; mtor controls ... See more keywords
Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016050508
Abstract: AKI is a frequent condition that involves renal microcirculation impairment, infiltration of inflammatory cells with local production of proinflammatory cytokines, and subsequent epithelial disorders and mitochondrial dysfunction. Peroxisome proliferator-activated receptor γ coactivator 1-α (PPARGC1A), a… read more here.
Keywords: respiration; hepatocyte nuclear; ppargc1a; factor ... See more keywords