Heterogeneity in COVID‐19 Convalescent Plasma Clinical Trials
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2281
Abstract: Due to the outbreak of the coronavirus disease 2019 (COVID19) pandemic, clinical trial (CT) research for efficacy and safety evaluation of convalescent plasma (CP) accelerated globally. In trial planning and approval, clinical researcher and regulatory… read more here.
Keywords: convalescent; covid convalescent; convalescent plasma; heterogeneity covid ... See more keywords
Neutralizing activity to SARS‐CoV‐2 in 1.2 to 10.0 month convalescent plasma samples of COVID‐19: A transversal surrogate in vitro study performed in Quito‐Ecuador
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27866
Abstract: Coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, was first reported in Wuhan, China, in December 2019. Diagnostic methods for the detection of the virus and seroconversion of… read more here.
Keywords: convalescent; neutralizing activity; plasma; quito ecuador ... See more keywords
Convalescent plasma as a treatment modality for Coronavirus Disease 2019 in Indonesia: A case reports
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2021.102444
Abstract: Introduction and Importance: Coronavirus Disease 2019 (COVID-19) has become a pandemic since the beginning of 2020. COVID-19 is also spreading very rapidly in Indonesia and so far, no definitive therapy has been found. Case presentation… read more here.
Keywords: convalescent plasma; disease 2019; coronavirus disease; convalescent ... See more keywords
Use of convalescent serum reduces severity of COVID-19 in nonhuman primates
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.108837
Abstract: Passive transfer of convalescent plasma or serum is a time-honored strategy for treating infectious diseases. Human convalescent plasma containing antibodies against SARS-CoV-2 is currently being used to treat COVID-19 patients where clinical efficacy trials are… read more here.
Keywords: convalescent; serum; pathology; severity ... See more keywords
Evaluation and correlation between SARS-CoV-2 neutralizing and binding antibodies in convalescent and vaccinated subjects
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Immunological Methods"
DOI: 10.1016/j.jim.2021.113197
Abstract: Since the first detection of a novel Coronavirus (SARS-CoV-2) in December 2019 in Wuhan (China), it has become crucial to assess and quantize the human humoral immune response after SARS-CoV-2 natural infection and/or vaccination. Having… read more here.
Keywords: sars cov; vaccinated subjects; convalescent; binding antibodies ... See more keywords
Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
Sign Up to like & getrecommendations! Published in 2021 at "Transfusion Clinique et Biologique"
DOI: 10.1016/j.tracli.2021.02.005
Abstract: Pathogen reduction technologies (PRT) have been recommended by many regulatory authorities to minimize the residual risk of transfusion-transmitted infections associated with COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are nowadays well… read more here.
Keywords: reduction technologies; convalescent plasma; pathogen reduction; convalescent ... See more keywords
Why are children less affected than adults by severe acute respiratory syndrome coronavirus 2 infection?
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-022-00857-2
Abstract: An adequate immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to not only clear the virus but also prevent tissue immunopathology. Because children generally experience a milder course of coronavirus disease… read more here.
Keywords: response; sars cov; covid; convalescent ... See more keywords
Passive immunisation of convalescent human anti-Zika plasma protects against challenge with New World Zika virus in cynomolgus macaques
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Vaccines"
DOI: 10.1038/s41541-020-00234-y
Abstract: Zika virus (ZIKV) causes neurological complications in susceptible individuals, highlighted in the recent South American epidemic. Natural ZIKV infection elicits host responses capable of preventing subsequent re-infection, raising expectations for effective vaccination. Defining protective immune… read more here.
Keywords: challenge; convalescent; anti; zikv ... See more keywords
Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection
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DOI: 10.1038/s41598-017-04447-5
Abstract: The radial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global research community. In this study, we have investigated the serum proteome alterations in non-severe vivax malaria patients before and during… read more here.
Keywords: vivax malaria; convalescent; proteomics analysis; vivax ... See more keywords
Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117089119
Abstract: Significance Using absolute quantification of both cytokines and metabolites from the plasmas of convalescent COVID-19 patients, machine-learning approaches identified that a combination of cytokines and metabolites can clearly discriminate convalescent patients with rapidly faded antibodies… read more here.
Keywords: gly pro; covid patients; convalescent; convalescent covid ... See more keywords
High‐titer post‐vaccine COVID‐19 convalescent plasma for immunocompromised patients during the first omicron surge
Sign Up to like & getrecommendations! Published in 2023 at "Transplant Infectious Disease"
DOI: 10.1111/tid.14055
Abstract: Transplant and hematologic malignancy patients have high Coronavirus disease 2019 (COVID‐19) mortality and impaired vaccination responses. Omicron variant evades several monoclonal antibodies previously used in immunocompromised patients. Polyclonal COVID‐19 convalescent plasma (CCP) may provide broader… read more here.
Keywords: convalescent; covid convalescent; immunocompromised patients; convalescent plasma ... See more keywords