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   Articles with "convection enhanced" as a keyword



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Widespread functional opsin transduction in the rat cortex via convection-enhanced delivery optimized for horizontal spread

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recommendations! Published in 2017 at "Journal of Neuroscience Methods"

DOI: 10.1016/j.jneumeth.2017.08.008

Abstract: BACKGROUND Widespread opsin expression in the cortex of rats, where transgenic models have not been established, is not practical to achieve with the traditional diffusion-based virus transduction methods (DBD). NEW METHOD We developed protocols for… read more here.

Keywords: cortex; delivery; method; convection enhanced ... See more keywords
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Longitudinal Monitoring of Gd-DTPA Following Convection Enhanced Delivery in the Brainstem.

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recommendations! Published in 2020 at "World neurosurgery"

DOI: 10.1016/j.wneu.2020.01.199

Abstract: BACKGROUND Convection-enhanced delivery (CED) has been introduced into contemporary therapeutic strategies for incurable brain neoplasms as diffuse intrinsic pontine glioma (DIPG). Therapeutic benefit in part is predictably dependent upon drug distribution within tumor. However, therapeutics… read more here.

Keywords: longitudinal monitoring; dtpa; convection enhanced; monitoring ... See more keywords
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Electrokinetic Convection-Enhanced Delivery of Solutes to the Brain.

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recommendations! Published in 2020 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.0c00037

Abstract: Pressure-induced infusion of solutions into brain tissue is used both in research and in medicine. In medicine, convection enhanced delivery (CED) is used to deliver agents to localized areas of the brain, such as with… read more here.

Keywords: medicine; delivery; convection enhanced; enhanced delivery ... See more keywords
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SURG-24. REPEAT CONVECTION-ENHANCED DELIVERY FOR DIFFUSE INTRINSIC PONTINE GLIOMA

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recommendations! Published in 2020 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaa215.871

Abstract: While the safety and efficacy of convection-enhanced delivery (CED) have been studied in patients receiving single dose drug infusions, agents for oncologic therapy require repeated or chronic infusions to maintain therapeutic concentrations. Repeat/chronic CED infusions… read more here.

Keywords: diffuse intrinsic; infusion; pontine glioma; intrinsic pontine ... See more keywords
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DDEL-08. CONVECTION-ENHANCED DELIVERY OF NIMUSTINE HYDROCHLORIDE (ACNU) AGAINST PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.043

Abstract: Abstract Diffuse intrinsic pontine gliomas (DIPGs) are amongst the most challenging tumors to treat. Surgery is not an option, the effects of radiation therapy are temporary, and no chemotherapeutic agent has demonstrated significant efficacy. Intracerebral… read more here.

Keywords: gliomas; delivery; convection enhanced; nimustine hydrochloride ... See more keywords
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DIPG-42. TOWARD MULTIMODALITY THERAPY FOR DIPG/DMG: DEVELOPMENT AND INVESTIGATION OF CRANIOSPINAL IRRADIATION AND CONVECTION-ENHANCED DELIVERY PDX MODELS

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.089

Abstract: Abstract BACKGROUND Diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG) are metastatic diseases, as demonstrated by early convection-enhanced delivery (CED) clinical trials in which prolonged local tumor control can sometimes be achieved, but… read more here.

Keywords: pdx models; delivery; convection enhanced; dipg ... See more keywords
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TRTH-18. COMBINED TOPOTECAN AND CARBOPLATIN THERAPY FOR DIPG SUPPRESSES CELL GROWTH IN VITRO AND IS WELL TOLERATED WHEN DELIVERED BY CONVECTION ENHANCED DELIVERY IN VIVO.

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recommendations! Published in 2017 at "Neuro-oncology"

DOI: 10.1093/neuonc/nox083.229

Abstract: AbstractDespite clinical advances, diffuse intrinsic pontine glioma (DIPG) remains universally fatal and urgently requires new treatment modalities to improve prognosis. Topotecan and carboplatin have formed treatment regimes for pediatric cancers as single agents with limited… read more here.

Keywords: therapy; topotecan carboplatin; convection enhanced; dipg ... See more keywords
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SCIDOT-38. DEVELOPMENT OF AN IMAGE-INFORMED MATHEMATICAL MODEL OF CONVECTION-ENHANCED DELIVERY OF NANOLIPOSOMES FOR INDIVIDUAL PATIENTS

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recommendations! Published in 2019 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noz175.1174

Abstract: 186-Rhenium nanoliposomes (RNL) are an experimental theranostic being investigated for the treatment of recurrent Glioblastoma. While traditional external beam therapy exposures healthy tissue to radiation, RNL has the potential to deliver extremely large doses (>… read more here.

Keywords: infusion; delivery; model; convection enhanced ... See more keywords

Stereotactic and Functional Neurosurgery Convection-Enhanced Delivery of Autologous Cerebrospinal Fluid Enhances Basal Ganglia Visualization during MRI-Guided Deep Brain Stimulation Surgery

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recommendations! Published in 2023 at "Stereotactic and Functional Neurosurgery"

DOI: 10.1159/000528738

Abstract: Introduction: The aim of this study was to determine the safety and feasibility of convection-enhanced delivery of autologous cerebrospinal fluid (CSF) for enhancing intraoperative magnetic resonance imaging (MRI) of the basal ganglia during stereotactic neurosurgery.… read more here.

Keywords: deep brain; convection enhanced; mri; infusion ... See more keywords
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Deformational changes after convection-enhanced delivery in the pediatric brainstem.

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recommendations! Published in 2020 at "Neurosurgical focus"

DOI: 10.3171/2019.10.focus19679

Abstract: OBJECTIVE In the brainstem, there are concerns regarding volumetric alterations following convection-enhanced delivery (CED). The relationship between distribution volume and infusion volume is predictably greater than one. Whether this translates into deformational changes and influences… read more here.

Keywords: brainstem; convection enhanced; infusion; deformational changes ... See more keywords

Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.

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recommendations! Published in 2019 at "Journal of neurosurgery"

DOI: 10.3171/2019.3.jns1963

Abstract: OBJECTIVE Intracerebral convection-enhanced delivery (CED) has been limited to short durations due to a reliance on externalized catheters. Preclinical studies investigating topotecan (TPT) CED for glioma have suggested that prolonged infusion improves survival. Internalized pump-catheter… read more here.

Keywords: infusion; enhanced delivery; convection enhanced; pump ... See more keywords