Antibiotic Resistance: Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA (Adv. Sci. 6/2020)
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DOI: 10.1002/advs.202070035
Abstract: In article number https://doi.org/10.1002/advs.201903117, Ji‐Xin Cheng and co‐workers report an endogenous chromophore‐based phototherapy platform to combat antibiotic‐resistance Staphylococcus aureus infections. Functional membrane microdomains of Staphylococcus aureus are catastrophically disrupted via photochemical decomposition of membrane‐bound carotenoid… read more here.
Keywords: staphylococcus aureus; conventional antibiotics; antibiotic resistance; membrane microdomains ... See more keywords
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections
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DOI: 10.1002/med.21879
Abstract: Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important effector immune defense molecules in multicellular organisms. AMPs exert their antimicrobial activities through several mechanisms; thus far, induction of drug resistance through AMPs… read more here.
Keywords: antibiotics synergistic; antimicrobial peptides; conventional antibiotics; peptides conventional ... See more keywords
Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria
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DOI: 10.1007/s00726-018-2673-9
Abstract: The necessity to develop therapeutic agents and strategies to abate the spread of antibiotic-resistant pathogens is prominent. Antimicrobial peptides (AMPs) provide scaffolds and inspiration for antibiotic development. As an AMP of shorter scaffold, eight dilipid… read more here.
Keywords: gram negative; conventional antibiotics; negative bacteria; ultrashort cationic ... See more keywords
Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections.
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DOI: 10.1016/j.addr.2021.113948
Abstract: Bacteria have developed a wealth of strategies to avoid and resist the action of antibiotics, one of which involves pathogens invading and forming reservoirs within host cells. Due to the poor cell membrane permeability, stability… read more here.
Keywords: intracellular infections; drug delivery; conventional antibiotics; repurposing conventional ... See more keywords
The interactive antimicrobial activity of Terminalia sericea Burch ex DC. leaf extracts and conventional antibiotics against bacterial triggers of selected autoimmune inflammatory diseases
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DOI: 10.1016/j.sajb.2020.06.013
Abstract: ABSTRACT Recent increases in antibiotic resistance and corresponding decreases in the development of new antimicrobial therapies have made new antibiotic discovery a high priority. Traditional medicines have potential for antibiotic discovery, although synergistic combinations consisting… read more here.
Keywords: terminalia sericea; extracts conventional; interactive antimicrobial; conventional antibiotics ... See more keywords
Small-Molecule Potentiators for Conventional Antibiotics against Staphylococcus aureus.
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DOI: 10.1021/acsinfecdis.7b00084
Abstract: Antimicrobial resistance constitutes a global health problem, while the discovery and development of novel antibiotics is stagnating. Methicillin-resistant Staphylococcus aureus, responsible for the establishment of recalcitrant, biofilm-related infections, is a well-known and notorious example of… read more here.
Keywords: staphylococcus aureus; potentiators conventional; small molecule; conventional antibiotics ... See more keywords
Highly Synergistic Effects of Melittin with Conventional Antibiotics Against Multidrug-Resistant Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa.
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DOI: 10.1089/mdr.2018.0016
Abstract: BACKGROUND Morbidity and mortality due to multidrug-resistant (MDR) bacteria are of great concern in burn patients. In this critical condition, synergism between antimicrobial peptides and conventional antibiotics would be a promising strategy. Accordingly, this study… read more here.
Keywords: isolates acinetobacter; melittin; conventional antibiotics; multidrug resistant ... See more keywords
Efficacy of Cathelicidin-Mimetic Antimicrobial Peptoids against Staphylococcus aureus
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DOI: 10.1128/spectrum.00534-22
Abstract: Staphylococcus aureus resistance is a consistent problem with a large impact on the health care system. Infections with resistant S. aureus can cause serious adverse effects and can result in death. ABSTRACT Staphylococcus aureus is… read more here.
Keywords: antimicrobial peptoids; care; conventional antibiotics; staphylococcus aureus ... See more keywords
Strategies against methicillin-resistant Staphylococcus aureus persisters.
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DOI: 10.4155/fmc-2017-0199
Abstract: Chronic Staphylococcus aureus infections are complicated by frequent relapses not only from the development of drug resistance to conventional antibiotics, but also through the formation of persister bacterial cells. Bacterial persisters are in a transient,… read more here.
Keywords: strategies methicillin; staphylococcus aureus; conventional antibiotics; aureus persisters ... See more keywords