Hypoxia‐driven immunosuppression by Treg and type‐2 conventional dendritic cells in HCC
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32419
Abstract: Hypoxia is one of the central players in shaping the immune context of the tumor microenvironment (TME). However, the complex interplay between immune cell infiltrates within the hypoxic TME of HCC remains to be elucidated. read more here.
Keywords: conventional dendritic; treg type; hypoxia driven; driven immunosuppression ... See more keywords
Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102402
Abstract: Summary Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated surface molecules.… read more here.
Keywords: cell state; cdc2; cdc1; conventional dendritic ... See more keywords
XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Nature medicine"
DOI: 10.1038/s41591-021-01344-3
Abstract: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH,… read more here.
Keywords: non alcoholic; liver; alcoholic steatohepatitis; pathology ... See more keywords
Unique IL-13Rα2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57815-z
Abstract: This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated… read more here.
Keywords: vector; viral vector; stat3; conventional dendritic ... See more keywords
Type II conventional dendritic cells of asthmatic patients with frequent exacerbations have an altered phenotype and frequency
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.00859-2019
Abstract: In recent decades it has become clear that dendritic cells (DCs) critically contribute to the development of T helper 2 (Th2)-mediated allergic diseases, such as asthma. Two main conventional DC (cDC) subsets, type 1 cDCs… read more here.
Keywords: frequent exacerbations; conventional dendritic; cells asthmatic; dendritic cells ... See more keywords
Long-Term Depletion of Conventional Dendritic Cells Cannot Be Maintained in an Atherosclerotic Zbtb46-DTR Mouse Model
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0169608
Abstract: Background and aims Increased evidence suggests a pro-atherogenic role for conventional dendritic cells (cDC). However, due to the lack of an exclusive marker for cDC, their exact contribution to atherosclerosis remains elusive. Recently, a unique… read more here.
Keywords: dtr; zbtb46 dtr; zbtb46; conventional dendritic ... See more keywords
Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00699
Abstract: Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells. We have recently shown that in mice precursors of cDCs, but not… read more here.
Keywords: clec9a mediated; ablation conventional; conventional dendritic; dendritic cells ... See more keywords
Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.712676
Abstract: Atopic dermatitis (AD) is a common pruritic inflammatory skin disease characterized by impaired epidermal barrier function and dysregulation of Thelper-2 (TH2)-biased immune responses. While the lineage of conventional dendritic cells (cDCs) are implicated to play… read more here.
Keywords: cdcs; conventional dendritic; atopic dermatitis; like inflammation ... See more keywords
Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1127485
Abstract: A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge this concept… read more here.
Keywords: cdc1 cluster; cell; cdc1; conventional dendritic ... See more keywords