From Tryptophan to Toxin: Nature's Convergent Biosynthetic Strategy to Aetokthonotoxin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12778
Abstract: Aetokthonotoxin (AETX) is a cyanobacterial neurotoxin that causes vacuolar myelinopathy, a neurological disease that is particularly deadly to bald eagles in the United States. The recently characterized AETX is structurally unique among cyanotoxins and is… read more here.
Keywords: tryptophan toxin; toxin nature; tryptophan; convergent biosynthetic ... See more keywords
Convergent biosynthetic transformations to a bacterial specialized metabolite
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0331-5
Abstract: Microbes produce specialized metabolites to thrive in their natural habitats. However, it is rare that a given specialized metabolite is biosynthesized via pathways with distinct intermediates and enzymes. Here, we show that the core assembly… read more here.
Keywords: convergent biosynthetic; gram; biosynthetic transformations; transformations bacterial ... See more keywords