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Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12778
Abstract: Aetokthonotoxin (AETX) is a cyanobacterial neurotoxin that causes vacuolar myelinopathy, a neurological disease that is particularly deadly to bald eagles in the United States. The recently characterized AETX is structurally unique among cyanotoxins and is…
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Keywords:
tryptophan toxin;
toxin nature;
tryptophan;
convergent biosynthetic ... See more keywords
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Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0331-5
Abstract: Microbes produce specialized metabolites to thrive in their natural habitats. However, it is rare that a given specialized metabolite is biosynthesized via pathways with distinct intermediates and enzymes. Here, we show that the core assembly…
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Keywords:
convergent biosynthetic;
gram;
biosynthetic transformations;
transformations bacterial ... See more keywords