Convergent chemoenzymatic synthesis and biological evaluation of a heparan sulfate proteoglycan syndecan-1 mimetic.
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DOI: 10.1039/d1cc00796c
Abstract: A new convergent chemoenzymatic synthesis strategy, integrating enzymatic synthesis of heparan sulfate, sortase A ligation, copper(i)-catalyzed alkyne-azide cycloaddition, and solid phase peptide synthesis, has been established to efficiently synthesize a mimetic of heparan sulfate proteoglycan… read more here.
Keywords: convergent chemoenzymatic; synthesis; sulfate proteoglycan; heparan sulfate ... See more keywords