Converging cellular themes for the hereditary spastic paraplegias
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DOI: 10.1016/j.conb.2018.04.025
Abstract: Hereditary spastic paraplegias (HSPs) are neurologic disorders characterized by prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. They are among the most genetically-diverse neurologic disorders, with >80 distinct genetic loci… read more here.
Keywords: hereditary spastic; cellular themes; spastic paraplegias; converging cellular ... See more keywords