Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis.
Sign Up to like & getrecommendations! Published in 2021 at "Kidney international"
DOI: 10.1016/j.kint.2021.06.030
Abstract: Adverse effects of calcineurin inhibitors (CNI), such as hypertension, hyperkalemia, acidosis, hypomagnesemia and hypercalciuria, have been linked to dysfunction of the distal convoluted tubule (DCT). To test this, we generated a mouse model with an… read more here.
Keywords: acidosis; calcineurin; distal convoluted; cnb1 mice ... See more keywords
WNK4 kinase: role of chloride sensing in the distal convoluted tubule
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000683
Abstract: Purpose of review This review focuses on recent efforts in identifying with-no-lysine kinase 4 (WNK4) as a physiological intracellular chloride sensor and exploring regulators of intracellular chloride concentration ([Cl-]i) in the distal convoluted tubule (DCT).… read more here.
Keywords: convoluted tubule; wnk4; distal convoluted; chloride ... See more keywords
High-resolution temporal transcriptomic profiling of the distal convoluted tubule identifies an early adaptive response to furosemide
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734632
Abstract: The distal convoluted tubule (DCT) undergoes hypertrophy and hyperplasia to increase salt absorption in response to physiologic and pathological stresses, and has been implicated in the development of loop-diuretic resistance. However, the molecular mechanisms underlying… read more here.
Keywords: convoluted tubule; distal convoluted; high resolution; physiology ... See more keywords