Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
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DOI: 10.1038/s41467-021-21833-w
Abstract: Multidimensional fitness landscapes provide insights into the molecular basis of laboratory and natural evolution. To date, such efforts usually focus on limited protein families and a single enzyme trait, with little concern about the relationship… read more here.
Keywords: multiple catalytic; cooperative mutational; conformational dynamics; pervasive cooperative ... See more keywords