Enantioselective Annulation of α,β-Unsaturated N-Acyliminium Ions with β-Keto Ester Enolates via Cooperative Palladium and Brønsted Acid Catalysis.
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DOI: 10.1021/acs.orglett.2c01265
Abstract: We herein report a cooperative palladium- and Brønsted acid-catalyzed strategy toward the first enantioselective annulation of in situ generated α,β-unsaturated N-acyliminium ions with chiral metal enolates. Novel polycyclic oxoisoindoles featuring three contiguous stereogenic centers have… read more here.
Keywords: unsaturated acyliminium; palladium nsted; nsted acid; acyliminium ions ... See more keywords