An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP‐dependent protein kinase A
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14610
Abstract: The cAMP‐dependent protein kinase A (PKA) is the archetypical eukaryotic kinase. The catalytic subunit (PKA‐C) structure is highly conserved among the AGC‐kinase family. PKA‐C is a bilobal enzyme with a dynamic N‐lobe, harbouring the Adenosine‐5′‐triphosphate… read more here.
Keywords: cooperativity; protein kinase; kinase; camp dependent ... See more keywords
Cooperativity of hydrogen bonding network in microsolvated biotin, the ligand of avidin class proteins
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4253-7
Abstract: Biotin is well known to be bound with exceptional strength by the avidin class of proteins. This ability comes from a match between the biotin-binding pocket of the protein and the structural elements of biotin,… read more here.
Keywords: class proteins; hydrogen; avidin class; hydrogen bonding ... See more keywords
Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108677
Abstract: We investigate the effect of the alcohol-induced increase in the content of CYP2E1 in human liver microsomes (HLM) on the function of CYP3A4. Membrane incorporation of the purified CYP2E1 into HLM considerably increases the rate… read more here.
Keywords: induced increase; cyp2e1; hlm; alcohol induced ... See more keywords
Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.12.036
Abstract: Human glucokinase (GCK) is the prototypic example of an emerging class of proteins with allosteric-like behavior that originates from intrinsic polypeptide dynamics. High-resolution NMR investigations of GCK have elucidated millisecond-timescale dynamics underlying allostery. In contrast,… read more here.
Keywords: heterogeneity; timescale dynamics; nanosecond timescale; cooperativity ... See more keywords
FTIR – spectroscopy of intermolecular interactions of pyrrole in solutions: The influence of media and cooperativity of hydrogen bonds
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.12.117
Abstract: Abstract FTIR spectral analysis of solvation effects on the absorption frequencies of N H stretching vibrations of pyrrole as well as its complexes with proton acceptors (B) was carried out. The comparative analysis of the… read more here.
Keywords: cooperativity; spectroscopy; influence; hydrogen bonds ... See more keywords
Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution.
Sign Up to like & getrecommendations! Published in 2017 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.7b00534
Abstract: Using synthetic polypeptides as a model system, the theories of helix-coil transition were developed into one of the most beautiful and fruitful subjects in macromolecular science. The classic models proposed by Schellman and Zimm-Bragg more… read more here.
Keywords: synthetic polypeptides; helix coil; solution; zimm ... See more keywords
Formation of Excimers in Isoquinolinyl Pyrazolate Pt(II) Complexes: Role of Cooperativity Effects.
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c02780
Abstract: The interplay between noncovalent interactions involving metal complexes may lead to the formation of aggregates (i.e., ground state dimers, trimers, n-mers, etc.), and this is often linked to dramatic changes in their physical and chemical… read more here.
Keywords: cooperativity effects; isoquinolinyl pyrazolate; formation; pyrazolate complexes ... See more keywords
On the Dynamic Behavior of Pacman Phosphanes─A Case of Cooperativity and Redox Isomerism.
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.3c00481
Abstract: In solution, the Pacman chlorophosphane (2Cl) shows fast exchange of the endo/exo-orientation of the two P-Cl bonds in the molecule featuring cooperativity. Experimental and quantum mechanical investigations of the inversion on the phosphorus(III) centers reveal… read more here.
Keywords: behavior pacman; dynamic behavior; redox isomerism; cooperativity ... See more keywords
Evidence of Cooperativity among van der Waals Interactions in Segmented Polysiloxane
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecules"
DOI: 10.1021/acs.macromol.8b01636
Abstract: The cooperativity of van der Waals interactions in biomolecules and supramolecular assemblies has drawn significant scientific attention due to its offering of seamless opportunities to generate new materials. However, the potential of such cooperativity in… read more here.
Keywords: van der; der waals; waals interactions; siloxane copolymer ... See more keywords
Gate Tunable Cooperativity between Vibrational Modes.
Sign Up to like & getrecommendations! Published in 2019 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b01219
Abstract: Coupling between a mechanical resonator and optical cavities, microwave resonators or other mechanical resonators have been used to observe interesting effects from sideband cooling to coherent manipulation of phonons. Here we demonstrate strong coupling between… read more here.
Keywords: cooperativity; cooperativity vibrational; vibrational modes; tunable cooperativity ... See more keywords
Spatial Coordination of Cooperativity in Silica-Supported Cu/TEMPO/Imidazole Catalytic Triad
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.8b01399
Abstract: Multifunctional catalysts obtained by the covalent immobilization of discrete molecular species on porous supports represent a unique approach to emulate some of the design principle and performances of enzymes. However, it is decisive in such… read more here.
Keywords: coordination cooperativity; spatial coordination; silica; catalytic triad ... See more keywords