A phyB-PIF1-SPA1 kinase regulatory complex promotes photomorphogenesis in Arabidopsis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12110-y
Abstract: CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) is a highly conserved E3 ubiquitin ligase from plants to animals and acts as a central repressor of photomorphogenesis in plants. SUPPRESSOR OF PHYA-105 1 family members (SPA1-SPA4) directly interact with COP1… read more here.
Keywords: cop1; kinase; pif1 spa1; phosphorylation ... See more keywords
COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating Arabidopsis hypocotyl elongation
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1708087114
Abstract: Significance CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) is an E3 ubiquitin ligase acting as a central repressor of seedling photomorphogenesis in plants. Many nuclear-localized COP1 substrates have been identified in the last two decades; however, whether COP1… read more here.
Keywords: degradation; cop1; microtubule associated; wdl3 ... See more keywords
HYL1-CLEAVAGE SUBTILASE 1 (HCS1) suppresses miRNA biogenesis in response to light-to-dark transition
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116757119
Abstract: Significance HYPONASTIC LEAVES 1 (HYL1)-CLEAVAGE SUBTILASE 1 (HCS1) is a novel negative regulator of microRNA (miRNA) biogenesis that degrades HYL1 in the cytoplasm. Furthermore, cytoplasm CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase inhibit HCS1-mediated HYL1 degradation.… read more here.
Keywords: cop1; hyl1; mirna biogenesis; hcs1 ... See more keywords
E3 Ubiquitin Ligase Constitutive Photomorphogenic 1 Regulates Differentiation and Inflammation via MAPK Signaling Pathway in Rabbit Articular Chondrocytes.
Sign Up to like & getrecommendations! Published in 2023 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0664
Abstract: Constitutive photomorphogenic 1 (COP1), is an E3 ubiquitin ligase that plays a role in the regulation of various cellular processes including cell growth, differentiation, and survival in mammals. In certain conditions such as overexpression or… read more here.
Keywords: differentiation inflammation; regulates differentiation; ubiquitin ligase; articular chondrocytes ... See more keywords
The SUMO Conjugation Complex Self-Assembles into Nuclear Bodies Independent of SIZ1 and COP11[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Physiology"
DOI: 10.1104/pp.18.00910
Abstract: SUMO conjugation activity causes the formation of SUMO nuclear bodies, which strongly overlap with COP1-containing nuclear bodies due to a VP motif in the E3 ligase SIZ1 that acts as bridge protein. Attachment of the… read more here.
Keywords: sumo conjugation; cop1; conjugation activity; nuclear bodies ... See more keywords
The C-terminal 17 amino acids of the photoreceptor UVR8 is Involved in the fine-tuning of UV-B signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.12977
Abstract: Plant UV-B responses are mediated by the photoreceptor UV RESISTANCE LOCUS 8 (UVR8). In response to UV-B irradiation, UVR8 homodimers dissociate into monomers that bind to the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1). The interaction… read more here.
Keywords: cop1; fine tuning; c27; amino acids ... See more keywords
Structural insight into UV-B–activated UVR8 bound to COP1
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn3337
Abstract: The CONSTITUTIVE PHOTOMORPHOGENIC 1-SUPPRESSOR OF PHYA-105 (COP1-SPA) complex is a central repressor of photomorphogenesis. This complex acts as an E3 ubiquitin ligase downstream of various light signaling transduced from multiple photoreceptors in plants. How the… read more here.
Keywords: insight activated; cop1; structural insight; activated uvr8 ... See more keywords
Cop1 Controls Macrophage Infiltration and Antitumor Immunity in TNBC.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2021-144
Abstract: Knockout of Cop1 inhibits M2 macrophage infiltration and enhances immunotherapy response in TNBC. read more here.
Keywords: cop1; controls macrophage; cop1 controls; macrophage infiltration ... See more keywords