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   Articles with "cop1" as a keyword



A phyB-PIF1-SPA1 kinase regulatory complex promotes photomorphogenesis in Arabidopsis

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-12110-y

Abstract: CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) is a highly conserved E3 ubiquitin ligase from plants to animals and acts as a central repressor of photomorphogenesis in plants. SUPPRESSOR OF PHYA-105 1 family members (SPA1-SPA4) directly interact with COP1… read more here.

Keywords: cop1; kinase; pif1 spa1; phosphorylation ... See more keywords

COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating Arabidopsis hypocotyl elongation

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recommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1708087114

Abstract: Significance CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) is an E3 ubiquitin ligase acting as a central repressor of seedling photomorphogenesis in plants. Many nuclear-localized COP1 substrates have been identified in the last two decades; however, whether COP1… read more here.

Keywords: degradation; cop1; microtubule associated; wdl3 ... See more keywords

HYL1-CLEAVAGE SUBTILASE 1 (HCS1) suppresses miRNA biogenesis in response to light-to-dark transition

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2116757119

Abstract: Significance HYPONASTIC LEAVES 1 (HYL1)-CLEAVAGE SUBTILASE 1 (HCS1) is a novel negative regulator of microRNA (miRNA) biogenesis that degrades HYL1 in the cytoplasm. Furthermore, cytoplasm CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase inhibit HCS1-mediated HYL1 degradation.… read more here.

Keywords: cop1; hyl1; mirna biogenesis; hcs1 ... See more keywords

COP1 controls light-dependent chromatin remodeling

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2312853121

Abstract: Significance COP1, an E3 ligase, plays a pivotal role in the regulation of photomorphogenesis in plants. This role is accomplished through its capacity to target and degrade various nuclear substrates via the ubiquitin/26S proteasome system.… read more here.

Keywords: controls light; cop1; cop1 controls; light dependent ... See more keywords
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E3 Ubiquitin Ligase Constitutive Photomorphogenic 1 Regulates Differentiation and Inflammation via MAPK Signaling Pathway in Rabbit Articular Chondrocytes.

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recommendations! Published in 2023 at "DNA and cell biology"

DOI: 10.1089/dna.2022.0664

Abstract: Constitutive photomorphogenic 1 (COP1), is an E3 ubiquitin ligase that plays a role in the regulation of various cellular processes including cell growth, differentiation, and survival in mammals. In certain conditions such as overexpression or… read more here.

Keywords: differentiation inflammation; regulates differentiation; ubiquitin ligase; articular chondrocytes ... See more keywords

The E3 ubiquitin ligase COP1 and transcription factors HY5 and RHD6 integrate light signaling and root hair development.

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recommendations! Published in 2024 at "Plant physiology"

DOI: 10.1093/plphys/kiae618

Abstract: Light signaling plays a substantial role in regulating plant development, including the differentiation and elongation of single-celled tissue. However, the identity of the regulatory machine that affects light signaling on root hair cell (RHC) development… read more here.

Keywords: root hair; light signaling; cop1; hair development ... See more keywords

The SUMO Conjugation Complex Self-Assembles into Nuclear Bodies Independent of SIZ1 and COP11[OPEN]

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recommendations! Published in 2018 at "Plant Physiology"

DOI: 10.1104/pp.18.00910

Abstract: SUMO conjugation activity causes the formation of SUMO nuclear bodies, which strongly overlap with COP1-containing nuclear bodies due to a VP motif in the E3 ligase SIZ1 that acts as bridge protein. Attachment of the… read more here.

Keywords: sumo conjugation; cop1; conjugation activity; nuclear bodies ... See more keywords
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The C-terminal 17 amino acids of the photoreceptor UVR8 is Involved in the fine-tuning of UV-B signaling.

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recommendations! Published in 2020 at "Journal of integrative plant biology"

DOI: 10.1111/jipb.12977

Abstract: Plant UV-B responses are mediated by the photoreceptor UV RESISTANCE LOCUS 8 (UVR8). In response to UV-B irradiation, UVR8 homodimers dissociate into monomers that bind to the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1). The interaction… read more here.

Keywords: cop1; fine tuning; c27; amino acids ... See more keywords

Structural insight into UV-B–activated UVR8 bound to COP1

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abn3337

Abstract: The CONSTITUTIVE PHOTOMORPHOGENIC 1-SUPPRESSOR OF PHYA-105 (COP1-SPA) complex is a central repressor of photomorphogenesis. This complex acts as an E3 ubiquitin ligase downstream of various light signaling transduced from multiple photoreceptors in plants. How the… read more here.

Keywords: insight activated; cop1; structural insight; activated uvr8 ... See more keywords

Abstract C005: Arylsulfatase B inhibits progression of malignant melanoma by COP1-mediated apoptosis in syngeneic and humanized mouse models

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recommendations! Published in 2025 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-25-c005

Abstract: The enzyme Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) removes the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and is required for C4S degradation in mammalian cells. Congenital, inactivating mutations of ARSB are the cause… read more here.

Keywords: malignant melanoma; cop1; arsb; arylsulfatase ... See more keywords

Abstract 1395: Constitutive photomorphogenesis (COP)-1 leads to apoptosis in B16F10 metastatic melanoma model

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-1395

Abstract: The E3 ubiquitin ligase Constitutive Photomorphogenesis (COP)-1 inhibits UVB-induced light activation in plants by interaction with UV Receptor (UVR)8 and effects on hypocotyl elongation (HY)5-induced growth. UVB is recognized as a causative factor in human… read more here.

Keywords: constitutive photomorphogenesis; cop1; arsb; melanoma ... See more keywords