Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02118-4
Abstract: Chromosome 8q gain is associated with poor clinical outcomes in prostate cancer, but the underlying biological mechanisms remain to be clarified. CSN5, a putative androgen receptor (AR) partner that is located on chromosome 8q, is… read more here.
Keywords: cancer; significance; cop9 signalosome; prostate cancer ... See more keywords
COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2018.02.09
Abstract: Background The COP9 signalosome (CSN) is an evolutionarily conserved complex composed of eight subunits (CSN1-CSN8). Among the CSN subunits, CSN5 and its dimerization partner CSN6 are the only two MPN (Mpr1-Pad1-N-terminal) domain-containing subunits. These two… read more here.
Keywords: cop9 signalosome; csn5 csn6; lung cancer; csn5 ... See more keywords
The COP9 signalosome complex regulates fungal development and virulence in the wheat scab fungus Fusarium graminearum
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1179676
Abstract: The COP9 signalosome (Csn) complex is an evolutionarily conserved complex that regulates various important cellular processes. However, the function of the Csn complex in pathogenic fungi remains elusive. Here, the distribution of Csn subunits in… read more here.
Keywords: cop9 signalosome; csn complex; complex regulates; csn ... See more keywords
The Cellular and Developmental Roles of Cullins, Neddylation, and the COP9 Signalosome in Dictyostelium discoideum
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.827435
Abstract: “Cullins (CULs) are a core components” of cullin-RING E3 ubiquitin ligases (CRLs), which regulate the degradation, function, and subcellular trafficking of proteins. CULs are post-translationally regulated through neddylation, a process that conjugates the ubiquitin-like modifier… read more here.
Keywords: cellular developmental; cop9 signalosome; roles cullins; cullins neddylation ... See more keywords
The COP9 Signalosome: A Multi-DUB Complex
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10071082
Abstract: The COP9 signalosome (CSN) is a signaling platform controlling the cellular ubiquitylation status. It determines the activity and remodeling of ~700 cullin-RING ubiquitin ligases (CRLs), which control more than 20% of all ubiquitylation events in… read more here.
Keywords: dub complex; dub; multi dub; csn ... See more keywords
Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11040497
Abstract: The COP9 signalosome (CSN) is a highly conserved eukaryotic multi-subunit enzyme, regulating cullin RING ligase activities and accordingly, substrate ubiquitination and degradation. We showed that the CSN complex of Saccharomyces cerevisiae that is deviated in… read more here.
Keywords: saccharomyces cerevisiae; cop9 signalosome; cerevisiae toolkit; signalosome research ... See more keywords