COPD is Associated with Epigenome-wide Differential Methylation in BAL Lung Cells.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0403oc
Abstract: DNA methylation patterns in chronic pulmonary obstructive disease (COPD) might offer new insights into disease pathogenesis. To assess methylation profiles in the main COPD target organ, we performed an epigenome-wide association study on bronchoalveolar lavage… read more here.
Keywords: epigenome wide; copd associated; methylation; gene ... See more keywords
Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression
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DOI: 10.1183/13993003.02006-2016
Abstract: Toll-like receptors (TLRs) and nucleotide-binding oligomerisation domain (NOD)-like receptors (NLRs) are two major forms of innate immune sensors but their role in the immunopathology of stable chronic obstructive pulmonary disease (COPD) is incompletely studied. Our… read more here.
Keywords: bacterial load; inflammation; copd; copd associated ... See more keywords
RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs
Sign Up to like & getrecommendations! Published in 2018 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-018-0603-y
Abstract: BackgroundThere is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes comprised by… read more here.
Keywords: analysis; identify copd; copd; bronchial epithelial ... See more keywords