Autophagy augmentation alleviates cigarette smoke‐induced CFTR‐dysfunction, ceramide‐accumulation and COPD‐emphysema pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.11.023
Abstract: ABSTRACT In this study, we aimed to investigate precise mechanism(s) of sphingolipid‐imbalance and resulting ceramide‐accumulation in COPD‐emphysema. Where, human and murine emphysema lung tissues or human bronchial epithelial cells (Beas2b) were used for experimental analysis.… read more here.
Keywords: accumulation; ceramide accumulation; copd emphysema; emphysema pathogenesis ... See more keywords
Recurrence of emphysema post-lung transplantation in a patient with alpha 1 antitrypsin deficiency (AATD)
Sign Up to like & getrecommendations! Published in 2020 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2020.101309
Abstract: The genetic disorder alpha 1 antitrypsin deficiency (AATD) results in reduced levels of alpha 1 antitrypsin (AAT) in the lung and an imbalance between AAT anti-protease activity and the activity of proteases that degrade elastin… read more here.
Keywords: copd emphysema; emphysema; alpha antitrypsin; lung transplantation ... See more keywords
Alpha-1 antitrypsin deficiency in patients with COPD/emphysema, bronchiectasis and asthma
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2020.4717
Abstract: Introduction: Alpha-1-antitrypsin deficiency (AATD) is a rare hereditary condition, which is characterized by low alpha-1 antitrypsin (AAT) serum levels. While the association between AATD and COPD/emphysema is indisputed, the association to bronchiectasis and asthma is… read more here.
Keywords: patients copd; copd emphysema; bronchiectasis asthma; alpha antitrypsin ... See more keywords