Identification and characterization of a new dapoxetine impurity by NMR: Transformation of N‐oxide by Cope elimination
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.11.029
Abstract: HIGHLIGHTSA novel dapoxetine impurity has been identified using IR, NMR and MS.The mechanism for the impurity formation was proposed and confirmed by synthesis and degradation studies.The synthesis of dapoxetine‐N‐oxide was completed for the first time.… read more here.
Keywords: degradation; dapoxetine; cope elimination; impurity ... See more keywords
Bioorthogonal Retro-Cope Elimination Reaction of N,N-Dialkylhydroxylamines and Strained Alkynes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c00885
Abstract: A bioorthogonal reaction between N,N-dialkylhydroxylamines and cyclooctynes is described. This reaction features a highly regioselective transformation between small, easily functionalizable reaction components with second-order rate constants reaching 84 M-1 s-1. The reaction is orthogonal to… read more here.
Keywords: reaction dialkylhydroxylamines; cope elimination; elimination reaction; reaction ... See more keywords