Severe phenotype of ATP6AP1‐CDG in two siblings with a novel mutation leading to a differential tissue‐specific ATP6AP1 protein pattern, cellular oxidative stress and hepatic copper accumulation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12237
Abstract: Congenital disorders of glycosylation (CDG) represent a wide range of >140 inherited metabolic diseases, continually expanding not only with regards to the number of newly identified causative genes, but also the heterogeneity of the clinical… read more here.
Keywords: tissue specific; atp6ap1; copper accumulation; mutation ... See more keywords
Assessment of copper accumulation in archived liver specimens from cats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x20961350
Abstract: Objectives The aim of this study was to assess hepatic copper concentrations and zonal distribution in cat liver specimens. Methods For this study, 121 archived, formalin-fixed, paraffin-embedded liver specimens from cats were used. Tissue sections… read more here.
Keywords: copper; liver specimens; hepatic copper; copper accumulation ... See more keywords
Inhibition of ASIC1a-Mediated ERS Improves the Activation of HSCs and Copper Transport Under Copper Load
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.653272
Abstract: Hepatolenticular degeneration (HLD) is an autosomal recessive genetic disease caused by the toxic accumulation of copper in the liver. Excessive copper will disrupt the redox balance in cells and tissues, causing ischemia, hypoxia, and inflammation.… read more here.
Keywords: inhibition asic1a; copper; expression; copper accumulation ... See more keywords
Copper Accumulation in the Lips of Brass Players: Case Report of a Rare Phenomenon
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DOI: 10.3390/dj10110203
Abstract: Work-related exposures affecting oral health are important factors of morbidity and decreased quality of life, which may emerge from numerous physical, chemical, or mental occupational exposures. Copper (Cu) is an important trace element, however, it… read more here.
Keywords: brass players; brass; report; copper accumulation ... See more keywords
Ulva compressa from Copper-Polluted Sites Exhibits Intracellular Copper Accumulation, Increased Expression of Metallothioneins and Copper-Containing Nanoparticles in Chloroplasts
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DOI: 10.3390/ijms221910531
Abstract: In order to analyze the mechanisms involved in copper accumulation in Ulva compressa, algae were collected at control sites of central and northern Chile, and at two copper-polluted sites of northern Chile. The level of… read more here.
Keywords: copper polluted; polluted sites; control; copper ... See more keywords