Single-Particle Resolution of Copper-Associated Annular α-Synuclein Oligomers Reveals Potential Therapeutic Targets of Neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00021
Abstract: Metal ions stabilize protein–protein interactions and can modulate protein aggregation. Here, using liquid-based atomic force microscopy and molecular dynamics simulations, we study the concentration-dependent effect of Cu2+ ions on the aggregation pathway of α-synuclein (α-Syn)… read more here.
Keywords: particle resolution; resolution copper; cu2 ions; microscopy ... See more keywords
Metagenomic Resolution of Functional Diversity in Copper Surface-Associated Marine Biofilms
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.02863
Abstract: We used metagenomic sequencing combined with morphological and chemical analyses to investigate microbial taxa and functions related to copper-resistance and microbiologically influenced corrosion in mature copper-associated biofilms in coastal seawater for 44 months. Facultative anaerobic… read more here.
Keywords: marine biofilms; copper; associated biofilms; copper associated ... See more keywords
The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.944682
Abstract: High-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but the underlying mechanisms and involved proteins are unknown. Here, we selected 90 copper-related proteins… read more here.
Keywords: copper; prognosis; copper related; related proteins ... See more keywords
D-Penicillamine: The State of the Art in Humans and in Dogs from a Pharmacological and Regulatory Perspective
Sign Up to like & getrecommendations! Published in 2021 at "Antibiotics"
DOI: 10.3390/antibiotics10060648
Abstract: Chelant agents are the mainstay of treatment in copper-associated hepatitis in humans, where D-penicillamine is the chelant agent of first choice. In veterinary medicine, the use of D-penicillamine has increased with the recent recognition of… read more here.
Keywords: medicine; regulatory perspective; humans dogs; copper associated ... See more keywords