Molecular features of copper binding proteins involved in copper homeostasis
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1590
Abstract: Copper has a wide and important role in biological systems, determining conformation and activity of many metalloproteins and enzymes, such as cytochrome oxidase and superoxide dismutase . Furthermore, due to its possible reactivity with nonspecific… read more here.
Keywords: copper binding; binding proteins; proteins involved; copper ... See more keywords
Investigating spectroscopic and copper-binding characteristics of organic matter derived from sediments and suspended particles using EEM-PARAFAC combined with two-dimensional fluorescence/FTIR correlation analyses.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.11.113
Abstract: Different environmental dynamics of sediment organic matter (SOM) and suspended particulate organic matter (SPOM) result in great disparities in characteristics and subsequent interactions with heavy metals. In this study, sediments and suspended particles were collected… read more here.
Keywords: copper binding; sediments suspended; suspended particles; matter ... See more keywords
Molecular dynamics simulations of copper binding to amyloid-β Glu22 mutants
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e03071
Abstract: We report microsecond timescale ligand field molecular dynamics simulations of the copper complexes of three known mutants of the amyloid-β peptide, E22G, E22Q and E22K, alongside the naturally occurring sequence. We find that all three… read more here.
Keywords: copper binding; molecular dynamics; simulations copper; binding amyloid ... See more keywords
Copper (II) binding properties of an octapeptide fragment from the R3 region of tau protein: A combined potentiometric, spectroscopic and mass spectrometric study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111358
Abstract: The copper(II) complexes of a peptide fragment of the R3 domain of tau protein (tau(326-333) Ac-GNIHHKPG-NH2) and its mutants (Ac-GNGHHKPG-NH2, Ac-GNIHHKAG-NH2, Ac-GNGAHKPG-NH2 and Ac-GNGHAKPG-NH2) have been studied by potentiometric and spectroscopic (UV-Vis, CD) methods. ESR… read more here.
Keywords: protein; copper binding; copper; spectroscopic ... See more keywords
Cu(I) Binding to Designed Proteins Reveals a Putative Copper Binding Site of the Human Line1 Retrotransposon Protein ORF1p.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c00057
Abstract: Long interspersed nuclear elements-1 (L1) are autonomous retrotransposons that encode two proteins in different open reading frames (ORF1 and ORF2). The ORF1p, which may be an RNA binding and chaperone protein, contains a three-stranded coiled… read more here.
Keywords: designed peptides; copper binding; domain; copper ... See more keywords
Defining the copper binding aptamotif and aptamer integrated recovery platform (AIRP).
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c6nr09408b
Abstract: The potential copper binding sites in aptamers have been predicted on the basis of secondary structures and the binding affinity of aptamers with copper. Out of the 4 aptamers (Cu-A1 to Cu-A4) selected by SELEX… read more here.
Keywords: copper binding; recovery; copper; aptamer integrated ... See more keywords
A Novel Copper-Binding Peptide That Self-Assembles Into a Transparent Antibacterial and Antiviral Coating
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.736679
Abstract: The health, economy, and quality of life all over the world are greatly affected by bacterial infections and viral outbreaks. Bacterial cells and viruses, such as influenza, can spread through contaminated surfaces and fomites. Therefore,… read more here.
Keywords: copper binding; antibacterial antiviral; novel copper; peptide self ... See more keywords
Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020287
Abstract: α-Synuclein (αSyn) constitutes the main protein component of Lewy bodies, which are the pathologic hallmark in Parkinson’s disease. αSyn is unstructured in solution but the interaction of αSyn with lipid membrane modulates its conformation by… read more here.
Keywords: binding redox; copper binding; syn; membrane ... See more keywords
Roles of Copper-Binding Proteins in Breast Cancer
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18040871
Abstract: Copper ions are needed in several steps of cancer progression. However, the underlying mechanisms, and involved copper-binding proteins, are mainly elusive. Since most copper ions in the body (in and outside cells) are protein-bound, it… read more here.
Keywords: copper binding; copper; binding proteins; breast cancer ... See more keywords
Copper(II) Binding by the Earliest Vertebrate Gonadotropin-Releasing Hormone, the Type II Isoform, Suggests an Ancient Role for the Metal
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21217900
Abstract: In vertebrate reproductive biology copper can influence peptide and protein function both in the pituitary and in the gonads. In the pituitary, copper binds to the key reproductive peptides gonadotropin-releasing hormone I (GnRH-I) and neurokinin… read more here.
Keywords: copper binding; releasing hormone; gonadotropin releasing; copper ... See more keywords
Copper-Binding Domain Variation in a Novel Murine Lysyl Oxidase Model Produces Structurally Inferior Aortic Elastic Fibers Whose Failure Is Modified by Age, Sex, and Blood Pressure
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126749
Abstract: Lysyl oxidase (LOX) is a copper-binding enzyme that cross-links elastin and collagen. The dominant LOX variation contributes to familial thoracic aortic aneurysm. Previously reported murine Lox mutants had a mild phenotype and did not dilate… read more here.
Keywords: lysyl oxidase; blood pressure; copper binding;