Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells
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DOI: 10.3390/cancers11050659
Abstract: High affinity copper binding to mitogen-activated protein kinase kinase 1 (MAP2K1, also known as MEK1) allosterically promotes the kinase activity of MEK1/2 on extracellular signal regulated kinases 1 and 2 (ERK1/2). Consequently, copper-dependent activation of… read more here.
Keywords: copper chelation; kinase; effects copper; colon ... See more keywords