Synthesis and characterization of 8-aminoquinolines, substituted by electron donating groups, as high-affinity copper chelators for the treatment of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2019.05.003
Abstract: Abstract The deregulation of copper homeostasis generates copper–amyloid aggregation and strongly participates in neuron damage in the brains of patients with Alzheimer's disease. Therefore, copper chelators able to regulate copper homeostasis should be considered as… read more here.
Keywords: copper chelators; copper; copper homeostasis; affinity ... See more keywords
Effect of Copper Chelators via the TGF-β Signaling Pathway on Glioblastoma Cell Invasion
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DOI: 10.3390/molecules27248851
Abstract: Glioblastoma multiforme (GBM) is a fast-growing and aggressive type of brain cancer. Unlike normal brain cells, GBM cells exhibit epithelial–mesenchymal transition (EMT), which is a crucial biological process in embryonic development and cell metastasis, and… read more here.
Keywords: cell; copper; copper chelators; invasion ... See more keywords