Modulation of Mitochondriotropic Properties of Cyanine Dyes by in Organello Copper‐Free Click Reaction
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700286
Abstract: Cyanine (Cy) dyes show a general propensity to localize in polarized mitochondria. This mitochondriotropism was used to perform a copper‐free click reaction in the mitochondria of living cells. The in organello reaction of dyes Cy3… read more here.
Keywords: click reaction; free click; copper free; reaction ... See more keywords
Green Approach for Copper‐Free Pd‐catalyzed Sonogashira Cross‐Coupling using Saponin‐Based Micellar Catalysis in Water at Ambient Temperature
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500436
Abstract: A micellar catalysis that is derived from commercially available saponin for copper‐free, Pd‐catalyzed Sonogashira cross‐coupling under mild reaction conditions has been developed. Using this green and sustainable method, a broad range of aryl/heteroaryl and alkyl… read more here.
Keywords: micellar catalysis; cross coupling; free catalyzed; cross ... See more keywords
Copper‐Free Synthesis of Cationic Glycidyl Triazolyl Polymers
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular Rapid Communications"
DOI: 10.1002/marc.202400416
Abstract: Abstract Copper‐free synthesis of cationic glycidyl triazolyl polymers (GTPs) is achieved through a thermal azide‐alkyne cycloaddition reaction between glycidyl azide polymer and propiolic acid, followed by decarboxylation and quaternization of the triazole unit. For synthesizing… read more here.
Keywords: synthesis cationic; gtp; free synthesis; cationic glycidyl ... See more keywords
In-situ multi-step pulsed vapor phase surface functionalization of zirconia nanoparticles via copper-free click chemistry
Sign Up to like & getrecommendations! Published in 2021 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2020.148254
Abstract: Abstract We report on multi-step copper-free vapor phase azide-alkyne click reactions for the functionalization of metal oxide nanopowders, automated with the atomic layer deposition (ALD) technique. The synthetic approach consists of the following reaction steps:… read more here.
Keywords: phase; surface; chemistry; copper free ... See more keywords
Utilizing a copper-free Sonogashira reaction in the synthesis of the leukotriene a4 hydrolase modulator batatasin IV
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152547
Abstract: Abstract Batatasin IV is a dihydrostilbenoid isolated from Chinese yams which was shown to have inhibitory activities against plant growth. Later studies showed that this compound may exhibit anti-inflammatory properties by inhibiting the epoxide hydrolase… read more here.
Keywords: batatasin; leukotriene hydrolase; copper free; hydrolase ... See more keywords
Gag HIV‑1 Virus-like Particles and Extracellular Vesicles Functionalization with Spike Epitopes of SARS-CoV‑2 Using a Copper-Free Click Chemistry Approach
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.4c00559
Abstract: Enveloped nanoparticles such as extracellular vesicles (EVs) and virus-like particles (VLPs) have emerged as promising nanocarriers capable of transporting bioactive molecules for drug delivery and vaccination. Optimized functionalization methodologies are required to increase the functionalization… read more here.
Keywords: extracellular vesicles; like particles; chemistry; sars cov ... See more keywords
Copper-Free Alternatives to Access Ketone Building Blocks from Grignard Reagents
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06202
Abstract: Grignard reactions are an efficient way to form carbon–carbon bonds with widespread applications in large-scale processes. Classically, the electrophiles of choice to form ketones from Grignard reagents are acid chlorides. The reactions are typically catalyzed… read more here.
Keywords: grignard reagents; alternatives access; copper free; free alternatives ... See more keywords
Addition of Lauryldimethylamine N-Oxide (LDAO) to a Copper-Free Click Chemistry Reaction Improves the Conjugation Efficiency of a Cell-Free Generated CRM197 Variant to Clinically Important Streptococcus pneumoniae Serotypes
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03481
Abstract: Strain-promoted azide–alkyne cycloaddition (SPAAC) reactions like click chemistry have the potential to be highly scalable, robust, and cost-effective methods for generating small- and large-molecule conjugates for a variety of applications. However, despite method improvements, the… read more here.
Keywords: copper free; click chemistry; reaction; chemistry ... See more keywords
Unlocking Copper-Free Interfacial Asymmetric C-C Coupling for Ethylene Photosynthesis from CO2 and H2O.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c10023
Abstract: Solar-driven carbon dioxide (CO2) reduction into C2+ products such as ethylene represents an enticing route toward achieving carbon neutrality. However, due to sluggish electron transfer and intricate C-C coupling, it remains challenging to achieve highly… read more here.
Keywords: asymmetric coupling; co2 h2o; co2; copper free ... See more keywords
Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc03368h
Abstract: Copper-free click chemistry has resulted in a change of paradigm, showing that artificial chemical reactions can occur on cell surfaces, in cell cytosol, or within the body. It has emerged as a valuable tool in… read more here.
Keywords: free click; click chemistry; vivo; chemistry ... See more keywords
Polyimidazolium Amphiphilic Dendrimers on Thiacalix[4]arene and Gallic Acid Platforms via Copper-free Click Chemistry: Synthesis, Self-Assembly and DNA Binding
Sign Up to like & getrecommendations! Published in 2025 at "Polymer Chemistry"
DOI: 10.1039/d5py00984g
Abstract: A divergent synthetic scheme based on copper-free click chemistry was used to obtain two types of bromine-containing dendrimers with thiacalix[4]arene or gallic acid core. These dendrimers were then terminated with... read more here.
Keywords: chemistry; click chemistry; free click; thiacalix arene ... See more keywords