Liver Expression of a MiniATP7B Gene Results in Long‐Term Restoration of Copper Homeostasis in a Wilson Disease Model in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30535
Abstract: Gene therapy with an adeno‐associated vector (AAV) serotype 8 encoding the human ATPase copper‐transporting beta polypeptide (ATP7B) complementary DNA (cDNA; AAV8‐ATP7B) is able to provide long‐term copper metabolism correction in 6‐week‐old male Wilson disease (WD)… read more here.
Keywords: copper homeostasis; copper; disease; mice ... See more keywords
Dissecting copper homeostasis in diabetes mellitus
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1614
Abstract: Diabetes Mellitus (DM) is characterized by elevated blood glucose levels (hyperglycemia). It can occur due to impaired secretion or action of the hormone insulin, which is produced by pancreatic beta‐cells to promote the entry of… read more here.
Keywords: homeostasis; homeostasis diabetes; copper homeostasis; dissecting copper ... See more keywords
New insights into copper homeostasis in filamentous fungi
Sign Up to like & getrecommendations! Published in 2019 at "International Microbiology"
DOI: 10.1007/s10123-019-00081-5
Abstract: Copper is a metal ion that is required as a micronutrient for growth and proliferation. However, copper accumulation generates toxicity by multiple mechanisms, potentially leading to cell death. Due to its toxic nature at high… read more here.
Keywords: homeostasis filamentous; copper homeostasis; filamentous fungi; copper ... See more keywords
Serum Copper Homeostasis in Hypertensive Intracerebral Hemorrhage and its Clinical Significance
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-017-1227-4
Abstract: This study was to investigate the alterations of serum copper homeostasis after hypertensive intracerebral hemorrhage (ICH), which is not yet clear. We recruited 85 hypertensive ICH patients and determined their serum levels of total copper… read more here.
Keywords: serum copper; copper homeostasis; copper; serum ... See more keywords
Synthesis and characterization of 8-aminoquinolines, substituted by electron donating groups, as high-affinity copper chelators for the treatment of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2019.05.003
Abstract: Abstract The deregulation of copper homeostasis generates copper–amyloid aggregation and strongly participates in neuron damage in the brains of patients with Alzheimer's disease. Therefore, copper chelators able to regulate copper homeostasis should be considered as… read more here.
Keywords: copper chelators; copper; copper homeostasis; affinity ... See more keywords
The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx344
Abstract: Abstract SCO1 is a ubiquitously expressed, mitochondrial protein with essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper homeostasis. SCO1 patients present with severe forms of early onset disease, and ultimately… read more here.
Keywords: heart; sco1stm stm; copper homeostasis; copper ... See more keywords
An important role for periplasmic storage in Pseudomonas aeruginosa copper homeostasis revealed by a combined experimental and computational modeling study
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.14086
Abstract: Biological systems require precise copper homeostasis enabling metallation of cuproproteins while preventing metal toxicity. In bacteria, sensing, transport, and storage molecules act in coordination to fulfill these roles. However, there is not yet a kinetic… read more here.
Keywords: storage; pseudomonas aeruginosa; copper homeostasis; copper ... See more keywords
A novel prognostic scoring model based on copper homeostasis and cuproptosis which indicates changes in tumor microenvironment and affects treatment response
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1101749
Abstract: Background: Intracellular copper homeostasis requires a complex system. It has shown considerable prospects for intervening in the tumor microenvironment (TME) by regulating copper homeostasis and provoking cuproptosis. Their relationship with hepatocellular carcinoma (HCC) remains elusive.… read more here.
Keywords: copper homeostasis; tumor; copper; homeostasis cuproptosis ... See more keywords
The Role of Copper Homeostasis at the Host-Pathogen Axis: From Bacteria to Fungi
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DOI: 10.3390/ijms20010175
Abstract: Copper is an essential trace element participating in many vital biological processes, however it becomes a toxic agent when in excess. Thus, precise and tight regulation of copper homeostasis processes, including transport, delivery, storage, detoxification,… read more here.
Keywords: pathogen; copper homeostasis; copper; host ... See more keywords
Advances in Understanding of the Copper Homeostasis in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042050
Abstract: Thirty-five thousand people die as a result of more than 2.8 million antibiotic-resistant infections in the United States of America per year. Pseudomonas aeruginosa (P. aeruginosa) is classified a serious threat, the second-highest threat category… read more here.
Keywords: homeostasis; pseudomonas aeruginosa; copper; copper homeostasis ... See more keywords