Copper induces cell death by targeting lipoylated TCA cycle proteins
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DOI: 10.1126/science.abf0529
Abstract: Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we… read more here.
Keywords: cell death; copper; copper induces; death ... See more keywords
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15040972
Abstract: It has been reported that disordered Cu metabolism is associated with several neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). However, the underlying mechanism is still unclear. In this study, 4-week-old male mice… read more here.
Keywords: cuproptosis; impairment mice; copper induces; induces cognitive ... See more keywords