PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
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DOI: 10.1038/s41467-024-50524-5
Abstract: Fluxes in human copper levels recently garnered attention for roles in cellular signaling, including affecting levels of the signaling molecule cyclic adenosine monophosphate. We herein apply an unbiased temporal evaluation of the signaling and whole… read more here.
Keywords: copper; level fluctuations; copper level; transcriptional repression ... See more keywords
Restrained management of copper level enhances the antineoplastic activity of imatinib in vitro and in vivo
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DOI: 10.1038/s41598-018-19410-1
Abstract: The present study was designed to investigate if elevated copper level can be targeted to enhance the efficacy of a significant anticancer drug, imatinib (ITB). The antineoplastic activity of this drug was assessed in the… read more here.
Keywords: drug; copper level; antineoplastic activity; level ... See more keywords