Copper-mediated oxidative pentafluoroethylthiolation of aryl boronic acids with TMSC2F5 and elemental sulfur
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.07.008
Abstract: Abstract A copper-mediated oxidative pentafluoroethylthiolation of aryl boronic acids with TMSC 2 F 5 and S 8 was developed. This reaction provides a new access to various aryl pentafluoroethyl thioethers. The use of 2-fluoropyridine as… read more here.
Keywords: boronic acids; mediated oxidative; copper mediated; pentafluoroethylthiolation aryl ... See more keywords
Quantification of Exosome Based on a Copper-Mediated Signal Amplification Strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01187
Abstract: Exosomes, a class of small extracellular vesicles, play important roles in various physiological and pathological processes by serving as vehicles for transferring and delivering membrane and cytosolic molecules between cells. Since exosomes widely exist in… read more here.
Keywords: based copper; copper mediated; copper; mediated signal ... See more keywords
Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00242
Abstract: Through the recently developed copper-mediated photoinduced living radical polymerization (CP-LRP), a novel and well-defined polymeric prodrug of the antimicrobial lipopeptide colistin has been developed. A colistin initiator (Boc5-col-Br2) was synthesized through the modification of colistin… read more here.
Keywords: polymerization; copper mediated; colistin; photoinduced living ... See more keywords
Copper-Mediated Radiosynthesis of [18F]Rucaparib.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02770
Abstract: The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation. The most successful… read more here.
Keywords: copper mediated; mediated radiosynthesis; rucaparib; 18f rucaparib ... See more keywords
Copper-Mediated Decarboxylative Coupling between Arylacetic Acids and 1,3-Dicarbonyl Compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02897
Abstract: A copper-mediated decarboxylative coupling reaction between arylacetic acids and 1,3-dicarbonyl compounds was described. Significantly, methanocycloocta[b]indoles were also obtained by sequential intramolecular dehydrocyclization process in some cases. This protocol featured a broad substrate scope, simple operations,… read more here.
Keywords: acids dicarbonyl; mediated decarboxylative; copper mediated; dicarbonyl compounds ... See more keywords
Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03223
Abstract: We report herein a copper-mediated ortho-C-H amination of anilines using oxalamide as the directing group and DMF as the amination reagent. This protocol tolerates various functional groups and shows good heterocyclic compatibility. Late-stage dimethylamination of… read more here.
Keywords: using dmf; copper mediated; ortho amination; amination ... See more keywords
Copper-Mediated Three-Component Reaction for the Synthesis of N-Acylsulfonamide on DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01675
Abstract: The DNA-encoded library (DEL) technology is a new method for discovering hit compounds for target proteins in the pharmaceutical industry. The N-acylsulfonamide functional group has been reported to exhibit various pharmacological activities, and based on… read more here.
Keywords: copper; dna; mediated three; copper mediated ... See more keywords
Copper-Mediated Nucleophilic Addition/Cascade Cyclization of Aryl Diynes.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03787
Abstract: Treatment of diyne substrates with sulfinate salts under the action of copper(II) triflate results in a cascade cyclization reaction. The reaction involves nucleophilic addition of the sulfinate and formation of two new C-C bonds with… read more here.
Keywords: copper mediated; mediated nucleophilic; nucleophilic addition; cascade cyclization ... See more keywords
Copper-Mediated Domino Cyclization/Trifluoromethylation/Deprotection with TMSCF3: Synthesis of 4-(Trifluoromethyl)pyrazoles.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03822
Abstract: A copper-mediated synthesis of 4-(trifluoromethyl)pyrazoles is described. In one step from readily accessible α,β-alkynic tosylhydrazones, a remarkable domino sequence of cyclization, trifluoromethylation, and detosylation takes place to furnish the 4-CF3 N-H pyrazole cores with good… read more here.
Keywords: copper mediated; cyclization trifluoromethylation; trifluoromethyl pyrazoles; synthesis trifluoromethyl ... See more keywords
Copper-Mediated SN2' Allyl-Alkyl and Allyl-Boryl Couplings of Vinyl Cyclic Carbonates.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02947
Abstract: A method for the copper-catalyzed borylmethylation and borylation of vinyl cyclic carbonates through an SN2' mechanism is reported. These singular reactions involve selective SN2' allylic substitutions with concomitant ring opening of the cyclic carbonate and… read more here.
Keywords: copper mediated; sn2 allyl; mediated sn2; allyl ... See more keywords
Diastereoselective Copper-Mediated Cross-Couplings between Stereodefined Secondary Alkylcoppers with Bromoalkynes.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00699
Abstract: A copper(I)-mediated cross-coupling of stereodefined secondary alkyllithiums with bromoalkynes provided stereodefined alkynes with high diastereoselectivity (dr up to 98:2). This cross-coupling was extended to various secondary alkyllithiums bearing a remote oxygen functionality, and the alkyne… read more here.
Keywords: diastereoselective copper; copper mediated; mediated cross; stereodefined secondary ... See more keywords