Copper‐Mediated C(sp2)‐S Coupling: a Strategy for the Preparation of S‐Aryl Dithiocarbamates
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202500419
Abstract: We developed an efficient copper‐mediated one‐pot, three‐component reaction for synthesizing S‐aryl dithiocarbamates from aliphatic amines, phenylboronic acid, and carbon disulfide. This approach proceeds under mild, ambient conditions without requiring a base or additional additives, significantly… read more here.
Keywords: chemistry; copper mediated; aryl dithiocarbamates; mediated sp2 ... See more keywords
Copper‐Mediated Decarboxylative Trifluoromethylselenolation of Alkynyl Carboxylic Acids with [Me4N][SeCF3]
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400851
Abstract: The synthesis of alkynyl trifluoromethyl selenoethers from copper‐mediated aerobic decarboxylative trifluoromethylselenolation of alkynyl carboxylic acids with [Me4N][SeCF3] is reported. The reaction proceeded smoothly under mild conditions and enabled the facile conversion of both aryl and… read more here.
Keywords: alkynyl carboxylic; copper mediated; trifluoromethylselenolation alkynyl; decarboxylative trifluoromethylselenolation ... See more keywords
N‐(Pyridin‐2‐yl)Amide‐Directed, Copper‐Mediated Cyanatation of Arene CH Bonds: A New Approach for the Synthesis of 3‐(Pyridin‐2‐yl)Quinazoline‐2,4(1H,3H)‐Diones
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.4953
Abstract: Herein, we report the efficiency of N‐(pyridine‐2‐yl)‐amide as a directing group for copper‐mediated coupling of arylamide with KOCN to give 3‐(pyridin‐2‐yl)quinazoline‐2,4(1H,3H)‐dione derivatives. These products were obtained through an intramolecular cyclization of in situ‐generated 2‐arylisocyanate intermediates. We… read more here.
Keywords: pyridin; pyridin quinazoline; copper mediated; pyridin amide ... See more keywords
Copper-mediated oxidative pentafluoroethylthiolation of aryl boronic acids with TMSC2F5 and elemental sulfur
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.07.008
Abstract: Abstract A copper-mediated oxidative pentafluoroethylthiolation of aryl boronic acids with TMSC 2 F 5 and S 8 was developed. This reaction provides a new access to various aryl pentafluoroethyl thioethers. The use of 2-fluoropyridine as… read more here.
Keywords: boronic acids; mediated oxidative; copper mediated; pentafluoroethylthiolation aryl ... See more keywords
Quantification of Exosome Based on a Copper-Mediated Signal Amplification Strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01187
Abstract: Exosomes, a class of small extracellular vesicles, play important roles in various physiological and pathological processes by serving as vehicles for transferring and delivering membrane and cytosolic molecules between cells. Since exosomes widely exist in… read more here.
Keywords: based copper; copper mediated; copper; mediated signal ... See more keywords
Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00242
Abstract: Through the recently developed copper-mediated photoinduced living radical polymerization (CP-LRP), a novel and well-defined polymeric prodrug of the antimicrobial lipopeptide colistin has been developed. A colistin initiator (Boc5-col-Br2) was synthesized through the modification of colistin… read more here.
Keywords: polymerization; copper mediated; colistin; photoinduced living ... See more keywords
Copper-Mediated Radiosynthesis of [18F]Rucaparib.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02770
Abstract: The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation. The most successful… read more here.
Keywords: copper mediated; mediated radiosynthesis; rucaparib; 18f rucaparib ... See more keywords
Copper-Mediated Decarboxylative Coupling between Arylacetic Acids and 1,3-Dicarbonyl Compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02897
Abstract: A copper-mediated decarboxylative coupling reaction between arylacetic acids and 1,3-dicarbonyl compounds was described. Significantly, methanocycloocta[b]indoles were also obtained by sequential intramolecular dehydrocyclization process in some cases. This protocol featured a broad substrate scope, simple operations,… read more here.
Keywords: acids dicarbonyl; mediated decarboxylative; copper mediated; dicarbonyl compounds ... See more keywords
Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03223
Abstract: We report herein a copper-mediated ortho-C-H amination of anilines using oxalamide as the directing group and DMF as the amination reagent. This protocol tolerates various functional groups and shows good heterocyclic compatibility. Late-stage dimethylamination of… read more here.
Keywords: using dmf; copper mediated; ortho amination; amination ... See more keywords
Copper-Mediated Three-Component Reaction for the Synthesis of N-Acylsulfonamide on DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01675
Abstract: The DNA-encoded library (DEL) technology is a new method for discovering hit compounds for target proteins in the pharmaceutical industry. The N-acylsulfonamide functional group has been reported to exhibit various pharmacological activities, and based on… read more here.
Keywords: copper; dna; mediated three; copper mediated ... See more keywords
A Copper-Mediated Radical α-Heteroarylation of Nitriles with Azobis(alkylcarbonitriles)
Sign Up to like & getrecommendations! Published in 2024 at "Organic Letters"
DOI: 10.1021/acs.orglett.3c03727
Abstract: A new practical method has been developed for the α-heteroarylation of aliphatic nitriles with heteroarenes and azobis(alkylcarbonitriles) using Cu(OAc)2 as an oxidizing agent. This method allows the easy construction of nitrile-, aryl-, and dialkyl-bearing quaternary… read more here.
Keywords: heteroarylation; copper mediated; mediated radical; azobis alkylcarbonitriles ... See more keywords