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   Articles with "coproheme decarboxylase" as a keyword



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Spectroscopic evidence of the effect of hydrogen peroxide excess on the coproheme decarboxylase from actinobacterial Corynebacterium diphtheriae

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recommendations! Published in 2022 at "Journal of Raman Spectroscopy"

DOI: 10.1002/jrs.6326

Abstract: Abstract The actinobacterial coproheme decarboxylase from Corynebacterium diphtheriae catalyzes the final reaction to generate heme b via the “coproporphyrin‐dependent” heme biosynthesis pathway in the presence of hydrogen peroxide. The enzyme has a high reactivity toward… read more here.

Keywords: hydrogen peroxide; coproheme decarboxylase; effect; heme ... See more keywords

Insights into the Active Site of Coproheme Decarboxylase from Listeria monocytogenes

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recommendations! Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00186

Abstract: Coproheme decarboxylases (ChdC) catalyze the hydrogen peroxide-mediated conversion of coproheme to heme b. This work compares the structure and function of wild-type (WT) coproheme decarboxylase from Listeria monocytogenes and its M149A, Q187A, and M149A/Q187A mutants.… read more here.

Keywords: coproheme; coproheme decarboxylase; decarboxylase listeria; listeria monocytogenes ... See more keywords
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Initial Steps to Engineer Coproheme Decarboxylase to Obtain Stereospecific Monovinyl, Monopropionyl Deuterohemes

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recommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2021.807678

Abstract: The oxidative decarboxylation of coproheme to form heme b by coproheme decarboxylase is a stereospecific two-step reaction. In the first step, the propionate at position two (p2) is cleaved off the pyrrole ring A to… read more here.

Keywords: engineer coproheme; decarboxylase; initial steps; propionate position ... See more keywords
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The Role of the Hydrogen Bond Network in Maintaining Heme Pocket Stability and Protein Function Specificity of C. diphtheriae Coproheme Decarboxylase

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recommendations! Published in 2023 at "Biomolecules"

DOI: 10.3390/biom13020235

Abstract: Monoderm bacteria accumulate heme b via the coproporphyrin-dependent biosynthesis pathway. In the final step, in the presence of two molecules of H2O2, the propionate groups of coproheme at positions 2 and 4 are decarboxylated to… read more here.

Keywords: pocket stability; coproheme decarboxylase; role; pocket ... See more keywords
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Reorienting Mechanism of Harderoheme in Coproheme Decarboxylase—A Computational Study

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23052564

Abstract: Coproheme decarboxylase (ChdC) is an important enzyme in the coproporphyrin-dependent pathway (CPD) of Gram-positive bacteria that decarboxylates coproheme on two propionates at position 2 and position 4 sequentially to generate heme b by using H2O2… read more here.

Keywords: coproheme decarboxylase; mechanism harderoheme; mechanism; reorienting mechanism ... See more keywords