Overexpression of COPS3 promotes clear cell renal cell carcinoma progression via regulation of Phospho–AKT(Thr308), Cyclin D1 and Caspase–3
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.02.025
Abstract: ABSTRACT The third subunit of the COP9 signalosome (COPS3) is associated with cell proliferation and tumorigenesis process in cancer. The present study showed that the expression level of COPS3 was upregulated in malignant cell lines… read more here.
Keywords: akt thr308; thr308 cyclin; cops3; phospho akt ... See more keywords
Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression
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DOI: 10.7150/jca.16201
Abstract: COPS3 encodes the third subunit of the COP9 signalosome and its aberrant expression is associated with many RITE (“Region of Increased Tumor Expression”) genes in lung cancer tissues. To elucidate the specific role of COPS3… read more here.
Keywords: tumor; cell; lung cancer; cops3 ... See more keywords